Alanyl tRNA synthetase polynucleoyides of staphlococcus

Details Alanyl tRNA synthetase polynucleoyides of staphlococcus Alanyl tRNA synthetase polynucleoyides of staphlococcus

1997-01-17

1998-07-07

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 4352523, 43525411, 435325, 4353201, 536 232, 536 243, C12N 900, C12N 1500, C12N 120, C07H 2104

Patent

active

057767505

ABSTRACT:
The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.

REFERENCES:
patent: 5561054 (1996-10-01), Kron et al.
Chang et al. (1990) Primary Structure of Alanyl-tRNA Synthetase and the Regulation of its mRNA Levels in Bombyx mori. J. Biol. Chem. 265 (34): 20898-20906.
Kron et al., "An immundominant antigen in Brugia malayi is an asparaginyl-tRNA synthetase", Febs Letters, 374 pp. 122-124 (1995).
Chalker, et al., "Analysis and toxic overexpression in Escherichia coli of a staphylococcal gene encoding isoleucyl-tRNA synthetase", Gene, 141, pp. 103-108 (1994).
Nilsen, et al., "Cloning and characterization of a potentially protective antigen in lymphatic filariasis", Proc. Natl. Acad. Sci. USA, 85, pp. 3604-3607 (1988).
Fraser, et al., The Minimal Gene Complement of Mycoplasma genitalium, Science, 270, pp. 397-403 (1995).
Putney, et al., "Cloning, Partial sequencing, and in Vitro Transcription of the Gene for Alanine tRNA Synthetase", The Journal of Biochemical Chemistry, 256, No. 1, pp. 205-211 (1981).
Fleischmann, et al., "Whole-Genome Sequencing and Assembly of Haemophilus Influenzae Rd", Science, 269, pp. 496-512 (1995) and EMBL Sequence Database, Accession No. L42093.

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