Alanyl tRNA synthetase from Staphylococcus aureus

Details Alanyl tRNA synthetase from Staphylococcus aureus Alanyl tRNA synthetase from Staphylococcus aureus

1998-01-23

2000-05-09

Hobbs, Lisa J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 435440, 5303871, 536 232, C12N 900, C12N 1500, C12Q 168, C07H 2104

Patent

active

060602945

ABSTRACT:
The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.

REFERENCES:
patent: 5561054 (1996-10-01), Kron et al.
Kron, et al., "An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase", FEBS Letters, 374 pp. 122-124 (1995).
Chalker, et al., "Analysis and toxic overexpression in Escherichia coli of a staphylococcal gene encoding isoleucyl-tRNA synthetase", Gene, 141, pp. 103-108 (1994).
Nilsen, et al., "Cloning and characterization of a potentially protective antigen in lymphatic filariasis", Proc. Natl. Acad. Sci. USA, 85, pp. 3604-3607 (1988).
Fraser, et al., The Minimal Gene Complement of Mycoplasma genitalium, Science, 270, pp. 397-403 (1995).
Putney, et al., "Cloning, Partial Sequencing, and in Vitro Transcription of the Gene for Alanine tRNA Synthetase", The Journal of Biochemical Chemistry, 256, No. 1, pp. 205-211 (1981).
Fleischmann, et al., "Whole-Genome Sequencing and Assembly of Haemophilus Influenzae Rd", Science, 269, pp. 496-512 (1995) and EMBL Sequence Database, Accession No. L42093.
Chang et al., "Primary Structure of Alanyl-tRNA Synthetase and the Regulationof Its mRNA Levels in Bombyx mori.", The Journal of Biochemical Chemistry., 265, (34), pp. 20898-20906.

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