Alanine 2,3-aminomutases and related polynucleotides

Details Alanine 2,3-aminomutases and related polynucleotides Alanine 2,3-aminomutases and related polynucleotides

2006-10-16

2011-10-04

Desai, Anand (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Isomerase

C435S116000, C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

08030051

ABSTRACT:
The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.

REFERENCES:
patent: 6248874 (2001-06-01), Frey et al.
patent: 7309597 (2007-12-01), Liao et al.
patent: 2002/0173637 (2002-11-01), Frey et al.
patent: 2003/0113882 (2003-06-01), Frey et al.
patent: 2005/0221466 (2005-10-01), Liao et al.
patent: 2009/0031453 (2009-01-01), Jessen et al.
patent: WO 01/16346 (2001-03-01), None
patent: WO 02/42418 (2002-05-01), None
patent: WO 03/062173 (2003-07-01), None
patent: WO 2005/118719 (2005-12-01), None
patent: WO2006-022664 (2006-03-01), None
patent: WO 2006/047589 (2006-05-01), None
patent: WO 2007/047680 (2007-04-01), None
patent: WO 2007/047773 (2007-04-01), None
Abe, T. et al., 1998, “High-performance liquid chromatographic determination of β-alanine, β-aminoisobutyric acid and γ-aminobutyric acid in tissue extracts and urine of normal and (aminooxy)acetate-treated rats,”J Chromatogr B. 712(1-2):43-9.
Chen, D. et al., 2000, “A novel 2,3-aminomutase encoded by the yodO gene ofBacillus subtilis: characterization and the observation of organic radical intermediates,”Biochem J. 348:539-549.
Chen, D. et al., 2001, “Identification of Lysine 346 as a Functionally Important Residue for Pyridoxal 5′-Phosphate Binding and Catalysis in Lysine 2,3-Aminomutase fromBacillus subtilis,” Biochemistry40(2):596-602.
Chirpich, T. P. et al., 1970, “Lysine 2,3.Aminomutase purification and properties of a pyridoxal phosphate and s-adenosylmethionine-activated enzyme,”J Biol. Chem245(7):1778-1789.
Dalluge, J. et al., 2005, “Discovery of enzymatic activity using stable isotope metabolite labeling and liquid chromatography—Mass spectrometry,”Anal Chem. 77:6737-6740.
Genbank Accession No. AAB81159.
Genbank Accession No. CAB13860.
Genbank Accession No. AE017175.
International Preliminary Examination Report & Written Opinion of PCT/US2005/038552 issued May 1, 2007.
International Search Report of PCT/US2005/038552 dated Feb. 26, 2006.
Kunst, F. et al., 1997, “The complete genome sequence of the Gram positive bacteriumBacillus subtilis,” Nature390:249-256.
Lieder, K. et al., 1998, “S-Adenosylmethionine-dependent reduction of lysine 2,3-aminomutase and observation of the catalytically functional iron sulfur centers by electron paramagnetic resonance ,”Biochemistry37:2578-2585.
MacBeath, G. et al., 1998, “UGA Read-Through Artifacts—When popular gene expression systems need a patch ,”Biotechniques24:789-794.
Parker, J, “Errors and alternatives in Reading the Universal Code ,”Microbiol. Rev.53(3):273-298.
Petrovich, R. M. et al.,J Biol. Chem.266(12):7656-7660.
U.S. Appl. No. 11/919,271, filed Oct. 25, 2005.

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