[ALA IL-8].sub.77 and [SER IL-8].sub.72 as Leukocyte adhesion in

Details [ALA IL-8].sub.77 and [SER IL-8].sub.72 as Leukocyte adhesion in [ALA IL-8].sub.77 and [SER IL-8].sub.72 as Leukocyte adhesion in

1992-10-19

1995-09-19

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

514886, 514 2, 514 8, 514 12, 530351, A61K 4505, A61K 3700, A61K 3710, C07K 1300

Patent

active

054513995

ABSTRACT:
A novel polypeptide [Ala IL-8].sub.77 is provided which is a potent modulator of neutrophil functions. The polypeptide factor and related compositions find use as anti-inflammatory agents and as therapeutics for clinical indications in which damage to vascular endothelium and other tissues occurs. The amino acid and nucleotide sequence of the factor and methods for its purification, recombinant production and pharmaceutical use are provided.

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