Aklavinone C-11 hydroxylase, gene coding for same, expression ve

Details Aklavinone C-11 hydroxylase, gene coding for same, expression ve Aklavinone C-11 hydroxylase, gene coding for same, expression ve

1995-10-31

1998-12-01

Knode, Marian C.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435195, 435 681, 4353201, 536232, 536 64, C12N 1500, C12N 914, C12P 2106, C07H 2104

Patent

active

058437355

ABSTRACT:
Aklavinone C-11 hydroxylase separated from Streptomyces sp.; a gene encoding same; an expression vector comprising said gene; a microorganism transformed with said vector; and a process for preparing novel hybrid anthracyclines by using said vector.

REFERENCES:
patent: 4373094 (1983-02-01), Oki et al.
patent: 4471052 (1984-09-01), Mitscher et al.
Filippini et al. "Streptomyces peucetius daunorubicin biosynthesis gene dnrF : sequence and heterologous expression". Microbiology. vol.141, pp. 1007-1016, 1995.
Niemi et al. "Hybrid anthracycline antibiotics : production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus". Microbiology. vol. 140, pp. 1351-1358, 1994.
Hong et al. "Molecular cloning and characterization of the aklavinone 11 hydroxylase gene of Streptomyces peucetius subsp. caesius ATCC 27952". Journal of Bacteriology. vol.176, No.22, pp. 7096-7101, Nov. 1994.
Niemi et al. "Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaaeus". Journal of Bacteriology. vol.177, No.10, pp. 2942-2945, May 1995.
Tanaka et al. "Chemical modification of anthracycline antibiotic". Journal of Antibiotic. vol.34, No.7, pp. 850-855, Jul. 1981.
Hwang et al. "Expression of Streptomyces peucetius gene for doxorubicin resistance and aklavinone 11 hydroxylase in Streptomyces galilaeus ATCC 31133 and productionof a hybrid aclacinomycin". Antimicrobial Agents and Chemotherapy. vol.39, No.7, pp. 1616-1621, Jul. 1995.
Yoshimoto et al. "Anthracycline antibiotic 2 hydroxyaclacinomycin". Japanes Journal of Antibiotic. vol.44, No.3, pp. 277-286, Sep. 1991.
Connors et al. "Biosynthesis of anthracyclines: enzymic conversion of aklanonic acid to aklavinone and e-rhodomycinone by anthracycline-producing streptomyces". Journal of General Microbiology. vol.136, pp. 1887-1894, 1990.
Oki Toshikazu, et al., "Production of Ninteen Anthracycline Compounds by Streptomyces Galilaeus MA 144-MI", J. Antibiotics, 1977, vol. XXX, No. 8, pp. 683-687.
Oki Toshikazu, et al., "Antitumor Anthracycline Antibiotics Aclacinomycin A and Analogues", J. Antibiotics, 1979, vol. XXX11, No.8, pp. 801-819.

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