Ajuga turkestanica extract and its cosmetic uses

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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C514S171000

Reexamination Certificate

active

07060693

ABSTRACT:
The invention relates to an extract of the plantAjuga turkestanicacontaining at least one ecdysteroid and at least one iridoid and obtainable by extraction of at least part of said plant by means of a solvent or solvent mixture consisting of 0 to 60% by weight of water, the remainder of said solvent or solvent mixture consisting of at least one C1to C4alcohol and/or acetone and/or butylene glycol and/or propylene glycol, and very particularly to an extract containing one part by weight of ecdysteroids to 2 to 4 parts by weight of iridoids.The invention further relates to cosmetic uses of these extracts or associations containing one part by weight of ecdysteroids to 2 to 4 parts by weight of iridoids as cosmetic agents for improving the differentiation of keratinocytes, for regulating the water fluxes and the water absorption in the epidermis or for hydrating the epidermis.The invention further relates to a method of cosmetic skin treatment in which a cosmetically effective amount of the extracts or associations defined above is applied.

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Mamatkhanov et al., “Isolation of Turkesterone from the Epigeal Part of Ajuga Turkestanica and its Anabolic Activity.”, Chemistry of Natural Compounds, vol. 34(2), pp. 150-154, 1998.
Syrov et al., “Effect of a lipid concentrate from the aboveground portion of Ajug turkestanica on the metabolic proceses and dynamics of healing skin wounds experimentally”. Pharmaceutical Chem. J., vol. 28(11), pp. 837-840, 1994.
Mamatkhanov, A.U., et al., “Isolation of Turkesterone from the Epigeal Part ofAjuga turkestanicaand its Anabolic Activity”. Chem. Nat. Compd., vol. 34, No. 2, pp. 150-154, (1998).
Kotenko, L.D., et al., “Monitoring of Total Iridoid Production by Ajuga Turkestanica”. Chemical Abstracts Service, vol. 123, No. 296372, (1994).
Syrov, V. N., et al., “Effect of a lipid concentrate from the aboveground portion ofAjuga turkestanicaon the metabolic processes and dynamics of healing skin wounds experimentally.” Pharmaceutical Chemistry Journal , vol. 28, No. 11, pp. 837-840, 1994.
Jung, Jin Sup, et al., “Molecular Structure of the Water Channel through Aquaporin CHIP”. J. Biol. Chem., vol. 269, No. 20, pp. 14648-14654, 1994.
Sougrat, R., et al., “Functional expression of AQP3 in human epidermis and keratinocyte cultures”. Molecular Biology of the Cell, vol. 9, p. 499a, 1998 (abstract only).

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