Ailanthone derivatives

Details Ailanthone derivatives Ailanthone derivatives

1985-01-15

1987-05-12

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549278, 514908, C07D49308

Patent

active

046652019

ABSTRACT:
Novel antineoplastic ailanthone derivatives (IIb) represented by the following formula wherein R.sub.2 is C.sub.5 -C.sub.18 .alpha.,.beta.-unsaturated acyl group and its related compounds are disclosed. ##STR1## Particularly, some of the above compounds are far more effective than mitomycin C against mouse lymphocytic leucemia p388.
These compounds can be synthesized from known ailanthone via important intermediates, triacyloxy ailanthone, represented by the formula: ##STR2## wherein R.sub.1 is acyl group.

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S. M. Krupchan et al., Jour. Org. Chem., vol. 40, No. 5 (Mar. 7, 1975) pp. 648-656.
John M. Cassady et al., Anticancer Agents Based on Natural Product Models, (1980), pp. 255-269.

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