Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1994-10-14
1999-08-10
Eisenschenk, Frank C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241841, 4242041, 4242081, 530300, 530327, 530350, 5303881, A61K 3921, A61K 3938, A61K 3912, A61K 3800
Patent
active
059355794
ABSTRACT:
The present invention provides therapy and prophylaxis against HIV-induced AIDS, as well as methods for ascertaining the susceptibility of an individual to HIV-induced AIDS, the invention being based on the discovery that AIDS results from gp120 of HIV mimicking the antigen-presenting component of the immune system, thereby spuriously activating certain CD4+ T cells in susceptible individuals, leading to a condition similar to graft versus host disease, the condition being treatable by eliminating the responsible T cells, for example.
REFERENCES:
patent: 4943628 (1990-07-01), Rosen et al.
Golding, et al., J. of Experimental Med., 167:914-923 (Mar. 1988).
Palker, et al, 1987, "A Conserved Region at the COOH Terminus . . . " PNAS 84: 2479-2483.
Yourno, et al, 1988, "Nucleotide Sequence Analysis of the Env . . . " AIDS Res. Hum. Retro. 4(3):165-73.
Helseth, et al, 1991, "Human Immunodeficiency Virus Type 1 sp120 Enevelope Glycoprotein Regions Important for Association with gp41 Transmembrane Glycoprotein" J. Virology 65(4):2119-2123.
Anand, et al, 1989, "Biological and Molecular Characterization of Human Immunodeficiency Virus (HIV-1.sub.Br) from the Brain of a Patient with Progressive Dementia". Virology 168: 79-89.
Cohen, 1993, "Jitters Jeopardize AIDS . . . " Science 262: 980-981.
Butini, et al, 1994, "Comparative Analysis of HIV . . . " J. Cellular Biochemistry, Suppl. 18B, Abstract J306.
Fox, 1994, "No Winners Against AIDS" Biotechnology 12: 128.
Helseth, et al, 1991, "Human Immunodeficiency Virus Type . . . " J. Virol. 65(4):2119-2123.
Vega, et al, 1990, "Autoimmune Response in AIDS" Nature 345:26.
Greene, 1993, "AIDS and the Immune System" Scientific American Sep. 1993, pp. 99-105.
Brown, 1993, "AIDS Vaccine Trials . . . " The Wash. Post. Newspaper, Jun. 10, 1993.
Bountiff Lynne
Dalgleish Angus George
Habeshaw John Anthony
Hounsell Elizabeth
Eisenschenk Frank C.
Nelson Brett
Retroscreen Limited
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