AIDS therapeutic agents comprising polymers formed from cinnamic

Details AIDS therapeutic agents comprising polymers formed from cinnamic AIDS therapeutic agents comprising polymers formed from cinnamic

1992-11-27

1997-05-27

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

514885, 526227, C08F 2062, A61K 31765

Patent

active

056329806

ABSTRACT:
AIDS therapeutic agents are provided which are less toxic, have a strong anti-AIDS virus activity and comprise as an effective ingredient a dehydrogenation polymer of a cinnamic acid derivative having a phenyl group substituted with at least one hydroxyl group or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 5223258 (1993-06-01), Machida et al.
P. Lai et al., "Modification of Human Immunodeficiency Viral Replication by Pine Cone Extracts", Aids Research and Human Retroviruses, vol. 6, No. 2, pp. 205-217 (1990).
Klocking et al., "Gewinnung, Charakterisierung und Antivirale Aktivitat von Phenolkorperpolymerisaten", Pharmazie, vol. 34, No. 5-6, 1979, pp. 292-295.
Sydow et al., "Zur Wirkung von Phenolkorperpolymerisaten auf Retroviren", Pharmazie, vol. 41, No. 12, 1986, pp. 865-868.
Hils et al., "Hemmung ausgewahlter Influenzavirusstamme der Typen A und B durch Phenolkorperpolymerisate", Biomedica Biochimica Acta, vol. 45, No. 9, 1986, pp. 1173-1179.
Sakagami et al., "Lignified Materials as a Potential Medicinal Resource. IV. Dehydrogenation Polymers of Some Phenylpropenoids and Their Capacity to Stimulate Polymorphonuclear Cell Iodination", Chem. Pharm. Bull., vol. 39, No. 4, 1991, pp. 950-955.

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