Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1987-02-24
1990-07-17
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 6, 435 7, 435810, G01N 33569
Patent
active
049421220
ABSTRACT:
A kit and a method for detecting the presence of an antibody inhibiting HIV (the AIDS virus) reverse transcriptase. The amount of antibody inhibiting HIV reverse transcriptase present in the body fluids of a patient known to be immunopositive for HIV gives the clinician a means to form a prognosis for each individual case.
REFERENCES:
Sarin et al., "Neutralization of HTLV-III/LAV Replication by Antiserum to Thymosin .beta..sub.1 ", Science, vol. 232 (1986) 1135-1137.
Taylor et al., "Prognostically Significant Classification of Immune Changes in Aids with Kaposi's Sarcoma", Blood, 67 (1986) 666-671.
Sano et al., "Antibody that Inhibits Immunodeficiency Virus Reverse Transcriptase and Association with Inability to Isolate Virus", Journal of Clinical Microbiology, 25 (1987):2415-2417.
Steimer et al., "Recombinant Polypeptide from the Endonuclease Region of the Acquired Immune Deficiency Syndrome Retrovirus Polymerase (pol) Gene Detects Serum Antibodies in Most Infected Individuals", Journal of Virology, 58 (1986):9-16.
Chandra et al., "Serological Relationship Between Reverse Transcriptases from Human T-Cell Lymphotropic Viruses Defined by Monoclonal Antibodies", FEBS Letters, 200 (1986):327-332.
B. F. Polk et al.: "Predictors of the Acquired Immunodeficiency Syndrome Developing in a Cohost of Seropositive Homosexual Men" New England Journal of Medicine; 316: 61 (1987).
J. Laurence et al. "Characterization and Clinical Association of Antibody Inhibitory to HIV Reverse Transcriptase Activity"; Science, 235, 1501-1504 (1987).
Imagawa David T.
Lee Moon H.
Sano Kouichi
Nucker Christine M.
Research Education Institute, Inc.
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