AICA riboside prodrugs

Details AICA riboside prodrugs AICA riboside prodrugs

1989-01-24

1992-01-21

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 23, A01N 43, A01N, A01N 3170, C07H 1702

Patent

active

050828290

ABSTRACT:
Prodrugs of AICA riboside are provided which increase the bioavailability of AICA riboside and thereby increase extracellular concentrations of the prophylactic and affirmative treatment of various pathologic conditions, including ischemia. Also provided are methods of using AICA riboside prodrugs in treating such conditions.

REFERENCES:
patent: 3910885 (1975-10-01), Moffatt
patent: 4575498 (1986-03-01), Holmes
patent: 4912092 (1990-03-01), Gruber
CA 83(21): 179457t (1975), J. Org. Chem. 40(20) Srivastava "Nucleosides of 4-Substituted Imidazoles".
CA 86(13): 90175p (1976) Chem. Pharm. Bull. 24(9) Miyoshi "Synthesis of 5-Amino-1-(3'-Deoxy-B-D) . . ."
CA 109(19): 170789a (1988) Nucleosides Nucleotides 7(3) chambers "Studies in the Protection & Deprotection . . ."

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