Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-09-16
2009-06-16
Solola, Taofiq A (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
07547726
ABSTRACT:
This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule inSalmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.
REFERENCES:
patent: 6559176 (2003-05-01), Bassler et al.
patent: 6720415 (2004-04-01), Bassler et al.
patent: 6780890 (2004-08-01), Bassler et al.
patent: 6844423 (2005-01-01), Bassler et al.
patent: 6864067 (2005-03-01), Bassler et al.
patent: WO 00/32152 (2000-06-01), None
patent: WO 00/32152 (2000-06-01), None
patent: WO 01/85664 (2001-11-01), None
patent: WO 01/85664 (2001-11-01), None
patent: WO 03/018046 (2003-03-01), None
patent: WO 03/064592 (2003-08-01), None
patent: WO 03/064592 (2003-08-01), None
patent: WO 2004/101826 (2004-11-01), None
patent: WO 2004/101826 (2004-11-01), None
Bassler, B. L. et al., “Small Talk: Cell-to-Cell Communication in Bacteria,” Cell 109, 421-424 (2002).
Bassler, B. L. et al., “Multiple signaling systems controlling expression of luminescence inVibrio harveyi: sequence and function of genes encoding a second sensory pathway,” Mol. Microbiol. 13, 273-286 (1994).
Bassler, B. L. et al., “Cross-Species Induction of Luminescence in the Quorum-Sensing BacteriumVibrio harveyi,” J. Bacteriol. 179, 4043-4045 (1997).
Chen, X. et al., “Structural identification of a bacterial quorum-sensing signal containing boron,” Nature 415, 545-549 (2002).
Cornell, K. A. et al., “Cloning and expression ofEscherichia coli5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase: Identification of thepfsgene product,” Biochim. Biophys. Acta 1396, 8-14 (1998).
Hayward, S. et al., “Improvements in the analysis of domain motions in proteins from conformational change: DynDom version 1.50,” J. Mol. Graph. Model. 21, 181-183 (2002).
Kellenberger, E. et al., “Comperative evaluation of eight docking tools for docking and virtual screening accuracy,” Proteins 57:225-242 (2004).
Lenz, D. H. et al., “The small RNA chaperone Hfq and multiple small RNAs control quorum sensing inVibrio harveyiandVibrio cholerae,” Cell 18, 69-82 (2004).
Lewis, H. A. et al., “A Structural Genomics Approach to the Study of Quorum Sensing: Crystal Structures of Three LuxS Orthologs,” Structure 9, 527-537 (2001).
Loomis, W. D. et. al., “Chemistry and biology of boron,” Biofactors 3, 229-239 (1992).
Meijler, M. M. et al., “Synthesis and Biological Validation of a Ubiquitous Quorum-Sensing Molecule,” Angew. Chem. Int. Ed. Engl. 43, 2106-2108 (2004).
Miller, M. B. et al., “Quorum Sensing in Bacteria,” Annu. Rev. Microbiol. 55, 165-199 (2001).
Miller, S. T. et al., “Salmonella typhimuriumrecognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2,” Mol. Cell 15, 677-687 (2004).
Perola, E. et al., “A detailed comparison of current docking and scoring methods on systems on pharmaceutical relevance,” Proteins 56:235-249 (2004).
Schauder, S., “The LuxS family of bacterial autoinducers: biosysnthesis of a novel quorum-sensing signal molecule,” Mol. Microbiol. 41, 463-476 (2001).
Surette, M. G. et al., “Quorum sensing inEscherichia coli, Salmonella typhimurium, andVibiro harveyi: A new family of genes responsible for autoinducer production,” Proc. Natl. Acad. Sci. USA 96, 1639-1644 (1999).
Taga, M. E. et al., “Chemical communication among bacteria,” Proc. Natl. Acad. Sci USA Suppl. 2 100, 14549-14554 (2003).
Taga, M. E. et al., “Lsr-mediated transport and processing of AI-2 inSalmonella typhimurium, ” Mol. Microbiol. 50, 1411-1427 (2003).
Taga, M. E. et al., “The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake inSalmonella typhimurium,” Mol. Microbiol. 42, 777-793 (2001).
Xavier, K. B. et al., “LuxS quorum sensing: more than just a numbers game,” Curr. Opin. Microbiol. 6, 191-197 (2003).
Zhao, G. et al., “Chemical Synthesis of S-Ribosyl-L-homocysteine and Activity Assay as a LuxS Substrate,” Bioorg. Med. Chem. Lett. 13, 3897-3900 (2003).
Bassler Bonnie L.
Campagna Shawn R.
Hughson Frederick M.
Miller Stephen T.
Semmelhack Martin F.
Porzio, Bromberg & Newman
Solola Taofiq A
The Trustees of Princeton University
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