AH receptor antagonists

Details AH receptor antagonists AH receptor antagonists

2007-04-30

2010-12-21

Witherspoon, Sikarl A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C568S330000, C514S680000, C514S684000

Reexamination Certificate

active

07855310

ABSTRACT:
The invention relates to the field of aryl hydrocarbon receptor (Ah receptor; AhR) antagonists and their uses.

REFERENCES:
patent: 2004/0147788 (2004-07-01), Savouret et al.
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patent: WO-02056858 (2002-07-01), None
Schreurs Richard H M M et al: “Examination of the in vitro (anti)estrogenic, (anti)androgenic and (anti)dioxin-like activities of tetraiin, indane and isochroman derivatives using receptor-specific bioassays.” Toxicology Letters Apr. 10, 2005, vol. 156, No. 2, Apr. 10, 2005, pp. 261-275, XP002447004 ISSN: 0378-4274 abstract, Compound N13 in Table 2 is inactive at ArH receptor.
Database CA [Online], Chemical Abstracts Service, Columbus, Ohio, US; Kerbal, Abdelali et al.: “Cycloaddition of some diarylnitrilimines to various 2-arylidene-l-indanones. Regio- and diastereochemistry of spiropyrazoline synthesis” XPOO2447009 retrieved from STN Database accession No. 1989:94258 abstract compounds with CAS-RNs 17434-31-0 and 17434-32-1 (R1=R2=Me in formula I of application) & Bulletin des Societes Chimiques Belles 97(2), 149-61 Coden:BSCBAG; ISSN: 0037-9646, 1988.
Database CA [Online], Chemical Abstracts Service, Columbus, Ohio, US; Imbach, Jean L. et al: “Nuclear magnetic resonance spectra of derivatives of various substituted indanones and tetralones” XP002447010 retrieved from STN Database accession No. 1967:490264 abstract, compound with CAS-RN 17434-31-0 (R1=R2=Me in formula I of application) & Tetrahedron , 23(10), 3931-41 Coden: TETRAB; ISSN: 0040-4020, 1967.
Database Medline [Online], US National Library of Medicine (NLM), Bethesda, MD, US; Nov. 2005, Tauchi Masafumi et al: “Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions.” XP002447011 Database accession No. NLM16227587 abstract & Molecular and Cellular Biology Nov. 2005, vol. 25, No. 21, Nov. 2005, pp. 9360-9368, ISSN: 0270-7306 cited in the application.
Database Medline [Online], US National Library of Medicine (NLM), Bethesda, MD, US; Jan. 18, 2000, Shimizu Y et al: “Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor.” XP002447012 Database accession No. NLM10639156 Abstract & Proceedings of the National Academy of Sciences of the United States of America Jan. 18, 2000, vol. 97, No. 2, Jan. 2000, pp. 779-782, ISSN: 0027-8424 cited in the application.

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