Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1997-12-18
2000-01-11
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514562, A61K 31195
Patent
active
060136723
ABSTRACT:
Astrocytes protect neurons from excitotoxic injury by maintaining low extra-cellular glutamate concentrations ([Glu].sub.o). Compromised astrocytic glutamate uptake has been implicated in acute and chronic neurological conditions, including Parkinson's disease. This invention provides evidence that [Glu].sub.o is modulated in a feed-back manner through activation of metabotropic glutamate receptors (mGluRs), particularly group II mGluRs. Furthermore, ACPD effects were mimicked by glutamate, suggesting that astrocytic glutamate transport is dynamically regulated with mGluRs acting as sensors for changes in [Glu]. Consequently, agonists of mGluR receptors are potent drugs to modulate extracellular glutamate levels in ways that are neuroprotective.
REFERENCES:
patent: 5622981 (1997-04-01), Eveleth et al.
Kaatz et al. Neuroscience (Oxford) 66(1), 55-65 (Abstract).
Sontheimer Harald W.
Ye Zu-Cheng
Adler Benjamin Aaron
Criares Theodore J.
UAB Research Foundation
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