Agonists of bitter taste receptors and uses thereof

Details Agonists of bitter taste receptors and uses thereof Agonists of bitter taste receptors and uses thereof

2011-08-16

2011-08-16

Ulm, John (Department: 1649)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100, C435S007210, C436S501000

Reexamination Certificate

active

07998692

ABSTRACT:
The present invention relates to agonists of the human bitter-taste receptor hTAS2R7 and its role in bitter taste transduction. The invention also relates to assays for screening molecules that modulate, e.g. suppress or block hTAS2R7 bitter taste transduction or bitter taste response.

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patent: WO 01/18050 (2001-03-01), None
patent: WO 2004/029087 (2004-04-01), None
Shi, P. et al. “Adaptive Diversification of Bitter Taste Receptor Genes in Mammalian Evolution”Mol. Biol. Evol., 2003, pp. 805-814, vol. 20, No. 5.
Chandrashekar, J. et al. “T2Rs Function as Bitter Taste Receptors”Cell, Mar. 17, 2000, pp. 703-711, vol. 100.
Pronin, A. N. et al. “Identification of Ligands for Two Human Bitter T2R Receptors”Chem. Senses, 2004, pp. 583-593, vol. 29.
Parry, C. M. et al. “Divergence of T2R chemosensory receptor families in humans, bonobos, and chimpanzees”PNAS, Oct. 12, 2004, pp. 14830-14834, vol. 101, No. 41.

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