Agonist peptide dimers

Details Agonist peptide dimers Agonist peptide dimers

1995-06-07

1998-06-16

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 530300, 530324, 530326, 530345, A61K 3800, C07K 200, C07K 500, C07K 700

Patent

active

057670781

ABSTRACT:
The present invention is directed to the dimerization of agonists and antagonists of cell surface receptors and particularly to peptide dimers which behave as cell surface receptor agonists in their dimeric form. Such receptors belong to the dimerization-mediated activation class often observed among receptors for growth and differentiation factors. The agonists of this class of receptors is understood to effect dimerization of the receptor and thus signal initiation. The present invention exemplifies dimers of erythropoietin (EPO) agonists and antagonists comprising a core amino acid sequence of X.sub.3 X.sub.4 X.sub.5 GPX.sub.6 TWX.sub.7 X.sub.8 (SEQ ID NO: 1) wherein each amino acid is indicated by standard one letter abbreviation; X.sub.3 can be C, A, .alpha.-amino-.gamma.-bromobutyric acid or Hoc; X.sub.4 can be R, H, L or W; X.sub.5 can be M, F, or I; X.sub.6 is independently selected from any one of the 20 genetically coded L-amino acids or the stereoisomeric D-amino acids; X.sub.7 can be D, E, I, L or V; and X.sub.8 can be C, A, .alpha.-amino-.gamma.-bromobutyric acid or Hoc, provided that either X.sub.3 or X.sub.8 is C or Hoc.

REFERENCES:
Vedovato et al. (1984) Acta. Haematol. 71:211-213.
Vichinsky et al. (1984) J. Pediatric 105:15-21.
Cotes et al. (1983) Brit. J. Ostet. Gyneacol. 90:304-311.
Haga et al. (1983) Acta Pediatr. Scand. 72:827-831.
Claus-Walker (1983) Acta Pediatr. Scand. 72:827-831.
Dunn et al. (1984) Eur. J. Appl. Physiol. 52:178-182.
Miller et al. (1982) Brit. J. Haematol. 52:545-590.
Upda et al. (1984) J. Lab. Clin. Med. 103:574-588.
Dainiak et al. (1983) Cancer 5:1101-1106.
Eschbach et al. (1987) N. Engl. J. Med. 316:73-78.
Krantz and Goldwasser (1984) Proc. Natl. Acad. Sci. USA, 81:7574-7578.
Branch et al. (1987) Blood 69:1782-1785.
Mayeux et al. (1987) FEBS Letters 211:22-223.
Mufson and Gesner (1987) Blood 69:1485-1490.
Sakaguchi et al. (1987) Biochem. Biophys. Res. Commun. 146:7-12.
Sawyer et al. (1987) Proc. Natl. Acad. Sci. USA, 84:3690-3694.
Sawyer et al. (1987) J. Biol. Chem. 262:5554-5562.
Todokoro et al. (1988) Proc. Natl. Acad. Sci. USA, 84:4126-4130.
Amagnosou et al. (1990) Proc. Natl. Acad. Sci. USA, 87:5978-5982.
Konishi et al. (1993) Brain Res. 609:29-35.
Heldin, et al., Ligand-Induced Dimerization of Growth Factor Receptors: Variations on the Theme, Cytokine Growth Factor Rev., vol. 7 No. 1, pp. 3-10, 1996.
Dorland's Illustrated Medical Dictionary, 27th Edition, pp. 1432-1433, 1988 .

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