Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Patent
1995-05-04
1999-12-07
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
4241431, 53038822, 5303891, 5303873, A61K 39395, C07K 1600
Patent
active
059978651
ABSTRACT:
Agonist antibodies are disclosed which bind to the extracellular domain of the flk2/flt3 receptor and thereby activate the intracellular kinase domain thereof. The labeled antibodies are useful as diagnostics for detecting the presence of the flk2/flt3 receptor in primitive hematopoietic cells for example. The antibodies are able to cause primitive hematopoietic cells to proliferate and/or differentiate and thereby enhance repopulation of mature blood cell lineages in a mammal which has undergone chemo- or radiation therapy or bone marrow transplantation. The antibodies are further useful for treating mammals which have suffered a decrease in blood cells as a consequence of disease or a hemorrhage, for example.
REFERENCES:
patent: 5087570 (1992-02-01), Weissman et al.
patent: 5199942 (1993-04-01), Gillis
patent: 5548065 (1996-08-01), Lemischka, I
Zeigler et al., "Cellular and Molecular Characterization of the Role of the FLK-2/FLT-3 Receptor Tyrosine Kinase in Hematopoietic Stem Cells" Blood 84(8):2422-2430 (1994).
Brizzi et al., "Hematopoietic Growth Factor Receptors" International Journal of Cell Cloning 9:274-300 (1991).
Fleming et al., "Functional Heterogeneity is Associated With the Cell Cycle Status of Murine Hematopoietic Stem Cells" Journal of Cell Biology 122(4):897-902 (1993).
Hannum et al., "Ligand for FLT3/FLK2 Receptor Tyrosine Kinase Regulates Growth of Haematopoietic Stem Cells and is Encoded by Variant RNAs" Nature 368:643 (1994).
Harrison et al., "Primitive Hemopoietic Stem Cells: Direct Assay of Most Productive Populations by Competitive Repopulation With Simple Binomial, Correlation and Covariance calculations" Experimental Hematology 21:206-219 (1993).
Jordan et al., "Cellular and Developmental Properties of Fetal Hematopoietic Stem Cells" Cell 61:953-963 (1990).
Ogawa, "Differentiation and Proliferation of Hematopoietic Stem Cells" Blood 81(11):2844-2853 (1993).
Rosnet et al., "Close Physical Linkage of the FLT1 and FLT3 Genes on Chromosome 13 in Man and Chromosome 5 in Mouse" Oncogene 8:173-179 (1993).
Waksal, "Chugai Backs ImClone to the Tune of $35 Million in Stem Cell Research" Biotechnology News 13(3) (Feb. 4, 1993).
Andrews et al., "Precursors of colony-forming cells in humans can be distinguished from colony-forming cells by expression of the CD33 and CD34 antigens and light scatter properties" Journal of Experimental Medicine 169:1721-1731 (1989).
Baumhueter et al., "Binding of L-selectin to the vascular sialomucin CD34" Science 262:436-438 (1993).
Berenson et al., "Antigen CD34+ Marrow Cells Engraft Lethally Irradiated Baboons" J. Clin. Invest. 81:951-955 (1988).
Better and Horwitz, "Expression of engineered antibodies and antibody fragments in microorganisms" Methods in Enzymology 178:476-496 (1989).
Bloom, B., "The Power of Negative Thinking" J. Clin. Invest. 91:1265-1266 (Apr. 1993).
Boggs et al., "Hematopoietic stem cells with high proliferative potential. Assay of their concentration in marrow by the frequency and duration of cure W/Wv mice" J. Clin. Inv. 70(2):242-253 (1982).
Civin et al., "Antigenic analysis of hematopoiesis--III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells" J. Immunol. 133(1):157-165 (1984).
Hardy et al., "Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow" Journal of Experimental Medicine 173:1213-1225 (1991).
Harlow et al. Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, Chapter 5, pp. 72-76 (1988).
Harrison et al., "Number and continuous proliferative pattern of transplanted primitive immunohematopoietic stem cells" Proc. Natl. Acad. Sci. 85(3):822-826 (1988).
Kiefer et al., "Fractionation of mouse bone marrow by adherence separates primitive hematopoietic stem cells from in vitro colony-forming cells and spleen colony-forming cells" Blood 78(10):2577-2582 (1991).
Larsson et al., "Characterization of murine thymic stromal-cell lines immortalized by temperature-sensitive simian virus 40 large T or adenovirus 5 Ela" Develop. Immunol. 1(4):279-293 (1991).
McNiece et al., "The role of recombinant stem cell factor in early B cell development. Synergistic interaction with IL-7" J. Immunol. 146:3785-3790 (1991).
Orlic and Bodine, "Pluripotent Hematopoietic Stem Cells of Low and High Density Can Repopulate W/Wv Mice" Exp. Hematol. 20:1291-1295 (1992).
Ploemacher et al., "An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse" Blood 74:2755-2763 (1989).
Rosnet et al., "Hematopoietic receptors of class III receptor-type tyrosine kinases" Critical Rev. in Oncogenesis 4:595-613 (1993).
Rosnet et al., "Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells" Blood 82:1110-1119 (1993).
Suda et al., "Proliferative kinetics and differentiation of murine blast cell colonies in culture: evidence for variable CO periods and constant doubling rates of early pluripotent hemopoietic progentiors" J. Cellular Physiology 117:308-318 (1983).
Sutherland et al., "Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro" Blood 74:1563-1569 (1989).
Osband, ME. et al. 1990 Immunol. Today 11:193-195.
Mamikawa, R. et al. 1995. Blood, 86(10 Suppl. 1) 449A.
Fletdier, FA. et al. 1995 Blood 86(10 Suppl. 1) 21A.
Birg et al., "Expression of the FMS/KIT-Like Gene FLT3 in Human Acute Leukemias of the Myeloid and Lymphoid Lineages" Blood 80(10):2584-2593 (1992).
Dosil et al., "Mitogenic Signalling and Substrate Specificity of the Flk2/Flt3 Receptor Tyrosine Kinase of Fibroblasts and Interleukin 3 Dependent Hematopoietic Cells" Molecular & Cellular Biology 13(10):6572-6585 (1993).
Kuczynski et al., "Stem Cell Kinase-1 (STK-1), Human Homologue of the Murine FLT3/FLK2 Tyrosine Kinase Receptor Gene, is Expressed on a Wide Variety of Non-Hematopoietic Tumor Cell Types" Blood 82(10):PA186 (1993).
Lyman et al., "Characterization of the protein encoded by the flt3 (flk2) receptor-like tyrosine kinase gene" Oncogene 8:815-822 (1993).
Lyman et al., "Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells" Cell 75:1157-1167 (1993).
Maroc et al., "Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 Receptor Tyrosine Kinase" Oncogene 8:909-918 (1993).
Matthews et al., "A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations" Cell 65:1143-1152 (1991).
Orlic et al., "Purification and Characterization of Heterogeneous Pluripotent Hematopoietic Stem Cell Populations Expressing High Levels of c-kit Receptor" Blood 82(3):762-770 (1993).
Rosnet et al., "Isolation and Chromosomal Localization of a Novel FMS-like Tyrosine Kinase Gene" Genomics 9:380-385 (1991).
Rosnet et al., "Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family" Oncogene 6:1641-1650 (1991).
Small et al., "STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells" Proc. Natl. Acad. Sci. USA 91:459 463 (1994).
Visser et al., "The Expression of Cytokine Receptors by Purified Hematopoietic Stem Cells" Stem Cells 11(2):49-55 (1993).
Yarden, "Agonistic Antibodies Stimulate the Kinase Encoded by the neu Protooncogene in Living Cells but the Oncogenic Mutant is Constitutively Active" Proc. Natl. Acad. Sci. USA 87:2569-2573 (1990).
Bennett Brian D.
Broz Susan D.
Matthews William
Zeigler Francis C.
Davis Minh-Tam
Feisee Lila
Lee Wendy M.
LandOfFree
Agonist antibodies against the flk2/flt3 receptor and uses there does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Agonist antibodies against the flk2/flt3 receptor and uses there, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Agonist antibodies against the flk2/flt3 receptor and uses there will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-820581