Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1992-03-23
1994-05-31
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
514343, 514660, 514813, A61K 4900, A61K 3144, A61K 3113
Patent
active
053167597
ABSTRACT:
A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or another agonist of the drug in an amount which would normally provide the desired pharmacologic effects and at least partially satiate the needs for the drug by a user. The method also comprises administering to the subject an antagonist to the drug or its other agonist in an amount sufficient to at least partially block the pharmacologic effects of the drug or its other agonist while there is a substantial amount of the drug or other agonist present in the system of the user. In one embodiment of the invention, the drug and the antagonist are administered substantially simultaneously so as to occupy a substantial portion of the receptors of the user for that drug thereby blocking or attenuating the effects of any further intake of the drug or other agonist. In another embodiment, the drug or its other agonist is first administered and the antagonist is self-administered by a subject in a manner which mimics the use of the drug thereby counter-conditioning the drug user to the stimuli associated with the normal administration of the drug. The invention further provides a method of therapeutically treating psychophysiologic diseases and disorders involving neuronal dysregulation. The method additionally provides a pharmacologic composition for the treatment and reduction of drug dependence and which relies upon a combination of an agonist and an antagonist.
REFERENCES:
patent: 2981641 (1961-04-01), O'Neill
patent: 3071509 (1963-01-01), O'Neill
patent: 4597961 (1986-07-01), Etscorn
Levin Edward D.
Rose Jed E.
Henley III Raymond J.
Schaap Robert J.
Schaap Robert J.
Waddell Frederick E.
LandOfFree
Agonist-antagonist combination to reduce the use of nicotine and does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Agonist-antagonist combination to reduce the use of nicotine and, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Agonist-antagonist combination to reduce the use of nicotine and will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1626495