Agonist and antagonist peptides of the C140 receptor

Details Agonist and antagonist peptides of the C140 receptor Agonist and antagonist peptides of the C140 receptor

1995-06-07

1998-06-09

Robinson, Douglas W.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

530300, 530328, 530329, 530330, C07K 700, A61K 3804

Patent

active

057635757

ABSTRACT:
Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.

REFERENCES:
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R. J. Kaufman, Methods in Enzymology, vol. 185, pp. 487-511 (1990): "Vectors Used for Expression in Mammalian Cells".
Masu et al., Nature, vol. 329, pp. 836-838 (1987): "cDNA Cloning of Bovine Substance-K Receptor Through Oocyte Expression System".
Scarborough et al., The Journal of Biological Chemistry, vol. 267 (19):13146-49 (1982): "Tethered Ligand Agonist Peptides".
Vu et al., Cell, vol. 64, pp. 1057-1068 (1991): "Molecular Cloning of a Functional Thrombin Receptor Reveals a Novel Proteolytic Mechanism of Receptor Activation".

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