Agonist and antagonist antibodies to the chemokine receptor-2 (C

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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53038823, 5303892, 5303896, 435 7021, 435 71, 435 72, 435334, 435326, 435331, 435335, 4241431, 4241451, 4241581, C07K 1624, C12N 1502

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060840757

ABSTRACT:
The invention relates to antibodies which is capable of binding the monocyte chemoattractant protein 1 (MCP-1) receptor CCR2, especially those which are capable of acting either as an antagonist or agonist. The claimed antobodies can be used for in vitro and/or in vivo diagnostic, for screening and detection of tissues and classes of cells expressing the MCP-1 receptor, for screening for new drugs and for therapeutic use. The invention also relates to a preparation comprising the claimed antibody and a micro-organism or cell-line capable of producing the claimed antibody.

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