Aglycons of A/16686 antibiotics

Details Aglycons of A/16686 antibiotics Aglycons of A/16686 antibiotics

1995-04-19

1996-02-13

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530317, 530323, C07K 754, A61K 3812, A61K 3815

Patent

active

054911281

ABSTRACT:
The invention concerns the aglycons of factors A1, A2, A3, A'1, A'2, A'3 of antibiotic A/16686, their corresponding tetrahydroderivatives and mixtures thereof. The aglycons are produced by the selective hydrolysis of antibiotic A/16686 factor A1, A2, A3, A'1, A'2 or A'3. The compounds have antibacterial activity against widely diffused gram positive bacteria and are particularly useful for topical treatment of wound infections and acne.

REFERENCES:
patent: 4303646 (1981-12-01), Cavalleri et al.
patent: 4427656 (1984-01-01), Cavalleri et al.
patent: 4661470 (1987-04-01), Malabarba et al.
patent: 5108988 (1992-04-01), Ciabatti et al.
Morita et al., J.C.S. Chem. Comm. pp. 874-875 (1978).
Cavalleri et al., The Journal of Antibiotics, vol. XXXVII, No. 4, pp. 309-317 (Apr. 1984).
Cavalleri et al., The Journal of Antibiotics, vol. XL, No. 1, pp. 49-59 (Jan. 1987).

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