Aglycons

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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Details

568326, 536 64, C07C 5702, C07C 49115

Patent

active

047314680

ABSTRACT:
The present invention relates to new aglycons which correspond to the general formula: ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and R.sub.5, which can be identical or different, represent a hydrogen atom or a group OH, OMetal or OR.sub.4, R.sub.4 being a substituted or unsubstituted C.sub.1 to C.sub.6 alkyl group,

REFERENCES:
patent: 4418192 (1983-11-01), Tanaka et al.
patent: 4465671 (1984-08-01), Angelucci et al.
The Journal of Organic Chemistry, vol. 48 (8):1328-1333 (Jun. 1982) Aklavin-Type Anthracyclinones: Brief, Regiospecific Syntheses of Tetracyclic Intermedicates by Frank M. Hauser et al.
Chemical Abstracts, vol. 101; Abstract No. 103524 q, "One-electron Reduction of Variously Substituted Anthraquinones", by A. Anne et al.
The Journal of Organic Chemistry, vol. 46 (13):2798-2804 (Jun. 19, 1981), Phenyl Selenide Anion, A Superior Reagent for the S.sub.n 2 Cleavage of Esters and Lactones, by Dennis Liotta et al.
The Journal of Antibiotics, vol. XXXIV (12):1596-1607 (Dec. 1981) Structure-Activity Relationships of Anthracyclines Relative to Cytotoxicity and Effects on Macromolecular Synthesis in L1210 Leukemia Cells by Matsuzawa (and Oki) et al. (4 authors).
Tetrahedron Letters, vol. 21 (35):3351-3354 (1980), A General Route to 11-Deoxyanthracyclines by J. P. Gesson et al.
Tetrahedron Letters, vol. 21 (18):4777-4780 (1980), The Vinyl Ketone Acetal Route to Aklavinone and 11-Deoxydaunomycinone by J. G. Bauman et al.
Tetrahedron Letters, vol. 22 (18):1667-1670 (1981), A Regiospecific Approach to 6-Deoxyanthracyclinones; The Structure of .gamma.-citromycinone by Andrew S. Kende et al.
J. Chem. Soc. Chem. Commun., 421-23 (1982) by Jean-Pierre Gesson et al., Total Synthesis of 11-Deoxydaunomycinone.

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