Electricity: measuring and testing – Electrolyte properties – Using a conductivity determining device
Patent
1984-06-14
1986-05-27
Eisenzopf, Reinhard J.
Electricity: measuring and testing
Electrolyte properties
Using a conductivity determining device
422 73, 324 65P, G01N 2707
Patent
active
045917930
ABSTRACT:
A disposable low cost electrode structure for measuring platelet aggregation in whole blood or PRP which utilizes conductive ink or foil for the electrodes with the electrode pattern printed, heat-stamped or silk-screened onto a suitable plastic non-reactive base. The base material can be any material which does not react with blood and is stiff enough, for example a polycarbonate, while the conductive element can be made with a silver conductive ink. The electrodes can be on one or both sides of the base or substrate material. Platelet aggregates start and build up on the leading edge of a narrow body inserted into the flow path of the blood. The conductive pattern must have its active element on or very near the leading edge of the electrode base material, and in contact with the blood, and the non-active areas of the conductive pattern must be insulated electrically from the blood or plasma being tested so as to allow sensing of the change in resistance caused by the platelet build-up on the active area. Tests of material thicknesses at stirring rates and in configurations that are used for aggregation indicate that the platelets will build up on physical thicknesses ranging from less than 0.005 inches up to about 0.025 inches. Above that, the platelets, which average in diameter about 2 to 3 microns, do not accumulate on the edge. The electrodes should have a means for making connection to the measuring circuit which will sense platelet aggregation by measuring the increase of resistance between the two legs of the electrode assembly.
REFERENCES:
patent: 4123701 (1978-10-01), Josefsen et al.
patent: 4301414 (1981-11-01), Hill et al.
patent: 4319194 (1982-03-01), Cardinal et al.
Eisenzopf Reinhard J.
O'Shea Kevin D.
Udell Walter B.
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