Aggrecanase structure

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S174000, C435S195000, C435S212000, C435S219000, C435S226000

Reexamination Certificate

active

07625731

ABSTRACT:
This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.

REFERENCES:
patent: 2002/0160492 (2002-10-01), Cook et al.
patent: 2005/0130973 (2005-06-01), Xiang et al.
patent: 2005/0143422 (2005-06-01), Levin et al.
patent: 2005/0277175 (2005-12-01), LaVallie et al.
patent: 2007/0178574 (2007-08-01), Mosyak et al.
patent: WO 2004/011637 (2004-02-01), None
Branden et al., “Introduction to Protein Structure Second Edition”, Garland Publishing Inc., New York, 1999.
Drenth, “Principles of X-ray Crystallography,” Springer, New York, 1995.
Kierzek et al., Biophys Chem 91:1-20, 2001.
Nagar et al., Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and Imatinib (STI-571), Cancer Research, vol. 62, p. 4236-4243, 2002.
Medline search results for “aggrecanase-2”, Retrieved from the Internet <URL: http://www.ncbi.nlm.nih.gov/sites/entrez>.
“The CCP4 Suite: Programs for Protein Crystallography,” Acta Crystallogr. Sect. D 50:760-763 (1994).
Abbaszade et al., “Cloning and Characterization of ADAMTS11, an Aggrecanase from the ADAMTS Family” J. Biol. Chem., 274(33):23443-23450 (1999).
Arner et al., “Aggrecanase. A target for the design of inhibitors of cartilage degradation” Ann N Y Acad Sci., 878:92-107 (1999).
Arner et al., “Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity” J. Biol Chem., 274(10):6594-6601 (1999).
Arner, “Aggrecanase-mediated cartilage degradation” Curr. Opin Pharmacol. 2(3):322-329 (2002).
De La Fortelle et al., “Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods,” Methods Enzym., 276:472-494 (1997).
Hedlund et al., “Association of the aggrecan keratan sulfate-rich region with collagen in bovine articular cartilage,” J Biol Chem. 274(9):5777-81 (1999).
Liu et al., “Aggrecanase: The Family and Its Inhibitors” Curr. Med. Chem.-Anti-Inflammatory & Anti-Allergy Agents 4:251-264 (2005).
Porter et al., “The ADAMTS Metalloproteinases” Biochem J. 386(1):15-27 (2005).
Rao, B.G., “Recent Developments in the Design of Specific Matrix Metalloproteinase Inhibitors Aided by Structural and Computational Studies”, Current Pharm. Design, 11:295-322 (2005).
Rush et al., “The application of x-ray, NMR, and molecular modeling in the design of MMP inhibitors,” Current Med. Chem. 4:1311-1327 (2004).
Seals et al., “The ADAMs family of metalloproteases: multidomain proteins with multiple functions,” Genes Dev. 17(1):7-30 (2003).
Skiles et al., “The Design, Structure, and Clinical Update of Small Molecular Weight Matrix Metalloproteinase Inhibitors”, Current Med. Chem., 11:2911-2977 (2004).
Skiles et al., “The Design, Structure, and Therapeutic Application of Matrix Metalloproteinase Inhibitors”, Current Med. Chem., 8:425-474 (2001).
Tortorella et al., “Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins”, Science 284:1664-1666 (1999).
Yasumoto et al., “The G1 Domain of Aggrecan Released from Porcine Articular Cartilage Forms Stable Complexes with Hyaluronan/Link Protein”, Rheumatology 42(2):336-342 (2003).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Aggrecanase structure does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aggrecanase structure, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aggrecanase structure will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4130689

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.