Aggrecanase

Details Aggrecanase Aggrecanase

2007-03-20

2007-03-20

Slobodyansky, Elizabeth (Department: 1652)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S226000, C435S252300, C435S320100, C435S325000

Reexamination Certificate

active

11285804

ABSTRACT:
A novel polypeptide, a polynucleotide encoding this polypeptide, an expression vector comprising this polynucleotide, a cell transfected with the expression vector, an antibody binding to the above polypeptide, a convenient screening method for obtaining an agent for treating joint diseases, and a process for manufacturing a pharmaceutical composition for treating joint diseases are disclosed.The polypeptide is a novel aggrecanase causative of joint diseases (particularly an OA disease).

REFERENCES:
patent: 6326162 (2001-12-01), Miller et al.
patent: 2003/0185828 (2003-10-01), Yamaji et al.
patent: 2004/0018555 (2004-01-01), Anderson et al.
patent: 2004/0053269 (2004-03-01), Todd et al.
patent: 9885131 (1999-02-01), None
patent: 998572 (1999-02-01), None
patent: 2001-511351 (2001-08-01), None
patent: 2003-144154 (2003-05-01), None
patent: WO 99/05291 (1999-02-01), None
patent: WO 03/027282 (2003-04-01), None
Apte (Dec. 1, 2000) GenBank accession AF163762.
Abbaszade et al., “Cloning and Characterization of ADAMTS11, an Aggrecanase from the ADAMTS Family,” J. Biological Chemistry, 1999, 274(33): 23443-23450.
Chapman et al., “Osteoarthritis-Susceptibility Locus on Chromosome 11q, Detected by Linkage,” Am. J. Hum. Genet., 1999, 65: 167-174.
Flannery et al., “Expression of ADAMTS Homologues in Articular Cartilage,” Biochem. Biophys. Res. Comm., 1999, 260: 318-322.
Loughlin et al., “Stratification Analysis of an Osteoarthritis Genome Screen-Suggestive Linkage to Chromosomes 4, 6, and 16,” Am. J. Hum. Genet., 1999, 65:1795-1798.
Tortorella et al., “Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins,” Science, 1999, 284: 1664-1666.
International Search Report for PCT Application PCT/JP01/11033, mailed Mar. 19, 2002.
Supplementary European Search Report for Application No. EP 01 27 1116, mailed Apr. 4, 2004.
Apte (Dec. 1, 2000) GenBank Accession AF163762.
Preliminary Amendment mailed Feb. 14, 2003, for U.S. Appl. No. 10/240,545.
Office Action mailed May 5, 2005, for U.S. Appl. No. 10/240,545.
Reply to Office Action mailed Aug. 4, 2005, for U.S. Appl. No. 10/240,545.
Notice of Allowance and Fee(s) Due mailed Sep. 21, 2005, for U.S. Appl. No. 10/240,545.

Affiliated with

Also associated with

Rating

Aggrecanase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aggrecanase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aggrecanase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3788666