Aggrecanase

Details Aggrecanase Aggrecanase

2006-08-22

2006-08-22

Slobodyansky, Elizabeth (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C536S023200

Reexamination Certificate

active

07094590

ABSTRACT:
A novel polypeptide, a polynucleotide encoding this polypeptide, an expression vector comprising this polynucleotide, a cell transfected with the expression vector, an antibody binding to the above polypeptide, a convenient screening method for obtaining an agent for treating joint diseases, and a process for manufacturing a pharmaceutical composition for treating joint diseases are disclosed.The polypeptide is a novel aggrecanase causative of joint diseases (particularly an OA disease).

REFERENCES:
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patent: WO 03/027282 (2003-04-01), None
Apte (Dec. 1, 2000) GenBank accession AF163762.
Abbaszade et al., “Cloning and Characterization ofADAMTS11, an Aggrecanase from the ADAMTS Family,” J. Biological Chemistry, 1999, 274(33): 23443-23450.
Chapman et al., “Osteoarthritis-Susceptibility Locus on Chromosome 11q, Detected by Linkage,” Am. J. Hum. Genet., 1999, 65: 167-174.
Flannery et al., “Expressionof ADAMTS Homologues in Articular Cartilage,” Biochem. Biophys. Res. Comm., 1999, 260: 318-322.
Loughlin et al., “Stratification Analysis of an Osteoarthritis Genome Screen-Suggestive Linkage to Chromosomes 4, 6, and 16,” Am. J. Hum. Genet., 1999, 65:1795-1798.
Tortorella et al., “Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins,” Science, 1999, 284: 1664-1666.
International Search Report for PCT Application PCT/JP01/11033, mailed Mar. 19, 2002.
Supplementary European Search Report for Application No. EP 01 27 1116, mailed Apr. 4, 2004 (3 pages).

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