Agglutination reagent and method of preparing same

Details Agglutination reagent and method of preparing same Agglutination reagent and method of preparing same

1987-09-18

1989-05-09

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 7, 435 36, 436511, 436533, 436547, 436818, G01N 33547, G01N 33569, G01N 33571

Patent

active

048289787

ABSTRACT:
An agglutination reagent is prepared by covalently attaching an immunoreactive species to polymeric particles through reactive groups in the species. After attachment, the species is chemically modified with an acylating, alkylating or sulfonylating agent thereby modifying primary or secondary amino groups. The reagent can be used in agglutination assays for a number of analytes, inclusing Streptococcus A antigen, human retroviruses or antibodies, human chorionic gonadotropin and other antibodies or antigens.

REFERENCES:
patent: 4590156 (1986-05-01), Dorsett
patent: 4591571 (1986-05-01), Kuboyama et al.
patent: 4690906 (1987-09-01), Duheille
patent: 4690908 (1987-09-01), Mochida
Maggio(ed), Enzyme-Immunoassay, CRC Press, Inc., Boca Raton, Fla., 1980, pp. 71-75.
Kaplan et al., Biochim. Biophys. Acta, 728 (1983), pp. 112-120.

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