Chemistry: analytical and immunological testing – For preexisting immune complex or auto-immune disease – Immune complex
Patent
1982-05-26
1984-01-24
Marantz, Sidney
Chemistry: analytical and immunological testing
For preexisting immune complex or auto-immune disease
Immune complex
436519, 436520, 436821, G01N 3354
Patent
active
044277792
ABSTRACT:
Method for detecting circulating immune complexes containing endogenously bound Clq. Capillary tubes are filled with a mixture of Clq coated GPO reagent cells, rabbit anti-Clq antibodies, and precipitate from the biological fluid sample containing immune complexes. The mixture is allowed to react and the tubes read for the presence or absence of agglutination indicative of the absence or presence of said immune complexes respectively.
REFERENCES:
patent: 3873684 (1975-03-01), Fujita
patent: 4062935 (1977-12-01), Masson et al.
patent: 4138213 (1979-02-01), Masson et al.
patent: 4141965 (1979-02-01), Soothill et al.
patent: 4143124 (1979-03-01), Masson
patent: 4210622 (1980-07-01), Soothill et al.
Zubler, R. H. et al., The .sup.125 I-Clq Binding Test For The Detection of Soluble Immune Complexes, In Vitro Methods In Cell-Mediated and Tumor Immunity, by Bloom & David, pp. 565-572, 1976 Acad. Press.
Lachmann, P. J., Studies with Monoclonal Antibodies to Complement Components, Immunology Today, 144, Aug. 1981.
Hautanen, A. et al., C3c-Binding ELISA For The Detection of Immunocoglutinins and Immunoglobulin Aggregates, Methods In Enzymology, vol. 74:39-588-591 (1981).
Pribor, H. C. et al., Circulating Immune Complexes, Clinical Forum, pp. 23-25, May 1979.
Hay, F. C. et al., Routine Assay For The Detection of Immune Complexes of Known Immunoglobulin Class Using Solid Phase Clq. Clin. Exp. Immunol., 24,396-400 (1976).
Nydegger, U. E. et al., Circulating Immune Complexes in the Serum in Systemic Lupus Erythematosus and in Carriers of Hepatitis B Antigen, J. Clin. Invest., 54:297-309, Aug. 1974.
Rossen, R. D. et al., Detection of Immune Complex-like Materials in Cancer Patient's Sera: A Comparative Study of Results Obtaining With a Clq Deviation and Clq Binding Tests, J. Lab Clin. Med., 191-204, Feb. 1978.
Rosen, R. D. et al., Blockade of the Humoral Immune Response: Immune Complexes In Cancer, Chapter 8, Cancer Immunology: vol. 7, Harold Waters, Garland Publication, 1980.
Theofilopoulos, A. N., The Raji, Conglutinin, and Anti-C3 Assays for the Detection of Complement-Fixing Immune Complexes, Methods in Enzymology, vol. 74:511-531, 1981.
Siersted, H. C. et al., Quantitation of Circulating Immune Complexes by Combined PEG Precipitation and Immunoglobulin Specific Radioimmunossay, Methods in Enzymology, vol. 74:538-543, 1981.
Glikmann, G. et al., Detection and Quantitation of Circulating Immune Complexes by the Clq-Protein A Binding Assay, Methods in Enzymology, vol. 74:571-587, 1981.
Virella, G. et al., Isolation of Soluble Immune Complexes from Human Serum: Combined Use of Polyethylene Glycol Precipitation, Gel Filtration, and Affinity Chromatography on Protein A-Sepharose, Methods In Enzymology, vol. 74:644-663, 1981.
Mayer, M. M., The Complement System, Chapter 14, Immunology, edited by Burnet, W. H. Freeman and Company, 1976.
Theofilopoulos, A. N. et al., The Biology and Detection of Immune Complexes, Advances in Immunology, 28:89, 1977.
Zubler, R. H. et al., Immune complexes in Clinical Investigation, Recent Advances in Clinical Immunology, Thompson R. A.-Editor Churchill Livingstone, New York, p. 125, 1977.
Carpentier, N. A. et al., Clinical Relevance of Circulating Immune Complexes in Human Leukemia, J. Clin. Invest., 60:874, 1977.
Poulton, T. A. et al., Immune Complexes in Ovarian Cancer, The Lancet, p. 72-73, l978.
Luthra, H. S. et al., Immune Complexes in Sera and Synovial fluids of Patients with Rheumatoid Arthritis, J. Clin. Invest., 56:458, 1975.
Grigor, R. et al., Systemic Lupus Erythematosus, Annals of the Rheumatic Diseases, 37:121-128, 1978.
Levinsky, J. et al., Serum Immune Complexes and Disease Activity In Lupus Nephritis, The Lancet, p. 564, Mar. 12, l977.
Theofilopoulos, A. N. et al., Detection of Immune Complexes: Techniques and Implications, Hospital Practice, p. 107, May 1980.
Horowitz, B. et al., Development of Hemagglutination Assays, Vox Sang, 33:324-334, 1977.
Yonemasu, K. et al., Clq: Rapid Purification Method For Preparation of Monospecific Antisera and for Biochemical Studies, The Journal of Immunology, 106, 2:304-313, 1971.
Gabriel, A. et al., Detection of Immune Complexes, Journal of Clin. Invest., 59:990-1001, May 1977.
Heusser, C. et al., Effect of Chemical and Enzymatic Radioiodination on In Vitro Human Clq Activities, Journal of Immunology, vol. 110, 3:820-828, Mar. 1973.
Harris Joanne L.
Reckel Rudolph P.
Hofer Mark A.
Marantz Sidney
Ortho Diagnostic Systems Inc.
LandOfFree
Agglutination-inhibition test method for detecting immune comple does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Agglutination-inhibition test method for detecting immune comple, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Agglutination-inhibition test method for detecting immune comple will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1287905