Agglutination assay

Chemistry: analytical and immunological testing – Involving antibody fragments

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436520, 436533, 436534, 436805, G01N 33546, G01N 33555, G01N 33563

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active

048290114

ABSTRACT:
A method of detecting the presence and/or amount (concentration) of an analyte in a sample is provided by forming a reaction medium containing (1) a sample; (2) a plurality of particles having a binding pair member bound to their surfaces; and (3) a monovalent complementary partner to the binding pair member to which is bound an analyte mimic or analyte binding partner; and detecting the presence or amount of agglutination of the particles in the reaction medium. In some cases a polyvalent receptor capable of binding to the analyte (and to the analyte mimic, if present) is also present in the reaction medium.

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patent: 4308026 (1981-12-01), Mochida
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patent: 4556642 (1985-12-01), Collet-Cassart
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patent: 4619904 (1986-10-01), Giaever et al.
Grubb, et al., Hereditary Serological Human Serum Groups ACTA PATH, et MICROBIOL, SCANDINAV, (1956) vol. unknown, pp. 390-398.
Nisonoff Introduction to Molecular Immunology, Second Edition Sinauer Associates, Inc., Sunderland, Mass., 1984.

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