Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1998-01-28
2000-07-25
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
560128, A61K 3120, C07C 69587
Patent
active
060937416
ABSTRACT:
The present invention relates to the use of the antiviral activity of exogenous leukotriene B.sub.4 (LTB.sub.4), variants and derivatives thereof as a therapeutic agent in viral infections caused by human and animal viruses. The present invention also relates to the use of LTB.sub.4 as an anti-neoplastic agent in the prophylaxis and treatment of cancers induced by tumor viruses and in other neoplasic diseases. The human and animal viruses are DNA viruses, such as parvoviridae, papovaviridae, adenoviridae, herpesviridae, poxviridae and hepadnaviridae; RNA viruses, such as picornaviridae, togaviridae, orthomyxoviridae, paramyxoviridae, coronaviridae, reoviridae, and filoviridae in general, and Retroviridae such as HIV-1 and HIV-2.
REFERENCES:
Papp et al. "Binding of prostacyclin by plasma glycoproteins" CA 104:82673, 1985.
Toshiki et al. "A patient in whom a PGE1 pharmaceutical was effective for herpes zoster together with diabetes mellitus" JICST 02675404, 1995.
Sinclair et al. "Eicosanoids and the liver" Medline 92063107, 1990.
Lycke "Virological aspects on herpesvirus infections" Medline 86151481, 1986.
Kalmar et al. "Effect of Eicosanoids . . . " CA 104:219747, 1986.
Schechter et al. "Characterization of a herpesvirus . . . " MEDLINE 88274329, 1988.
Nuhn et al. "Synergistic effect of a . . . " Derwent Abst. 87-29888, 1987.
Murphy "The molecular biology of leukocyte chemoattractant receptors" CA 122:7234, 1994.
Hertting et al. "Formation and function of Eicosanoids in the CNS" Ann. N. Y. Aca. Sci. v. 559, 1989.
Bevilacqua et al., PNAS USA 84: 9238-9242, 1987.
Boyum A., Scand. J. Immunol., 1976 5(5):9.
Bray, R.A. et al., J. Immunol, 1986, 136:1783.
Cecil's Text Book of Medicine chapter 164, 19th Edition, 1992.
Cotran et al., J. Exp. Med. 164: 661-666, 1986.
Devchand P.R., et al., Nature 384:39, 1996.
Gagnon L., et al., Cell Immunol., 1987, 110:243.
Marleau, et al., Br. J. Pharmacol, 112: 654, 1994.
Marleau, et al., J. Immunol. 150: 206,1993.
Matthews and Boehms, Rev Inf. Dis., 1988, 10, suppl. 3:490.
Mehl J.K., et al., Antimicrob. Agents Ch. 18: 269, 1980.
Miller G., Virology, B.N. Fields & D.M. Knipe ed., Raven Press, 1990, pp. 1921-1958.
Reedman B.M. and Klein G., Int. J. Cancer, 11:499, 1973.
Remington's Pharmaceutical Sciences, 16th ed. Osol. A., ed., Mack, Easton PA, 1980.
Rola-Pleszczynski M. et al., Biochem. Biophys. Res. Comm., 1982, 108: 1531.
Rola-Pleszczynski M. et al., Biochem. Biophys. Res. Comm., 1983, 113:531.
Rola-Pleszczynski M. et al., Prostaglandins Leukotrienes Med., 1984, 13:113.
Steinhart W.L., et al., Virology 70:241, 1976.
Borgeat Pierre
Gosselin Jean
Chang Ceila
Virocell Inc.
LandOfFree
Agents with leukotriene B4-like activity as antiherpes viral age does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Agents with leukotriene B4-like activity as antiherpes viral age, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Agents with leukotriene B4-like activity as antiherpes viral age will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1336974