Agents useful for inactivation of Ras subfamily proteins

Details Agents useful for inactivation of Ras subfamily proteins Agents useful for inactivation of Ras subfamily proteins

2005-02-01

2005-02-01

Nickol, Gary B. (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S825000, C530S387300

Reexamination Certificate

active

06849715

ABSTRACT:
A method of treating a disorder characterized by an activating mutation in a Ras proto-oncogene, comprising contacting cells of a patient suffering from the disorder with a protein having the toxic activity ofClostridium sordelliitoxin LT under conditions favoring inactivation of Ras by glucosylation of Ras' threonine 35 in said cell. The protein preferably is an immunotoxin that contains as a toxic domain the catalytic domain of toxin LT.

REFERENCES:
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