Agents that modulate DNA-PK activity and methods of use thereof

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S320100, C435S252800, C435S174000, C435S183000, C382S129000, C382S133000, C382S153000, C382S173000, C382S286000, C382S291000, C702S019000, C702S022000, C536S022100, C536S023100, C536S024100, C536S024500, C530S300000, C530S350000

Reexamination Certificate

active

06893821

ABSTRACT:
The present invention provides methods for modulating cell death in a eukaryotic cell, and methods for reducing DNA damage in a eukaryotic cell. The methods generally comprise modulating a biological activity of DNA-PK in a cell. The invention further provides methods of treating a condition related to cell death in an individual. The invention further provides methods of identifying agents which modulate a biological activity of DNA-PK, as well as agents identified by the methods. Methods of modulating an immune response using an identified agent are also provided.

REFERENCES:
patent: 6441158 (2002-08-01), Dynan
patent: WO 9911275 (1999-03-01), None
patent: WO 9933971 (1999-07-01), None
patent: WO 0067023 (2000-11-01), None
Muller, et al. Blood 92(7):2213-2219, 1998.*
Lees-Miller et al., Molecular and Cellular Biology 10(12):6472-6481, 1990.*
Finnie, et al, Proc. Natl. Acad. Sci. USA 92:320-324, 1995.*
Han, et al., Journal of Biological Chemistry 271:14098-14104, 1996.*
Klinman, et al., Proc Natl Acad Sci USA 93:2879-2883, 1996.*
Munoz, et al., Molecular and Cellular Biology 18:5797-5808 1998.*
Krieg, et al., Nature 374:546-549, 1995.*
Anderson (1993) “DNA damage and the DNA-activated protein kinase.”TIBS, vol. 18: 433-437.
Anderson et al. (1998) “The Nuclear Serine/Threonine Protein Kinase DNA-PK.”Critical Reviews in Eukaryotic Gene Expression, vol. 2(4): 283-314.
Basu et al. (1998) “The DNA Dependent Protein Kinase Participates in the Activation of NFKB Following DNA Damage.”Biochemical and Biophysical Research Communication, vol. 247:79-83.
Boulton et al. (1998) “Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing.”The EMBO Journal, vol. 17(6): 1819-1828.
Casellas et al. (1998) “Ku80 is required for immunoglobulin isotype switching.”The EMBO Journal, vol. 17 (8):2404-2411.
Chu (1997) “Double Strand Break Repair.”The Journal of Biological Chemistry, vol. 272(39):24097-24100.
Cohen et al. (1992) “Apoptosis and Programmed Cell Death in Immunity.”Annu. Rev. Immunol., vol. 10:267-93.
Duvall et al. (1986) “Death and the cell.”Immunology, vol. 7(4):115-119.
Dynan et al. (1998) “Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids.”Nucleic Acids Research, vol. 26 (7):1551-1559.
Gerschenson et al. (1992) “Apoptosis: A different type of cell death.”FASEB J., vol. 6:2450-2455.
Giffin et al. (1997) “Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase.”The Journal of Biological Chemistry, vol. 272 (9):5647-5658.
Hammarsten et al. (2000) “Activation of DNA-dependent Protein Kinase by Single-stranded DNA Ends. ”The Journal of Biological Chemistry, vol. 275 (3):1541-1550.
Klinman et al. (1999) “Immune Recognition of Foreign DNA: A Cure for Bioterrorism?”Immunity, vol. 11:123-129.
Leuther et al. (1999) “Structure of DNA-dependent protein kinase: implications for its regulation by DNA.”The EMBO Journal, vol. 18 (5):1114-1123.
MacFarlene et al. (1997) “Unmethylated CpG-containing oligodeoxynucleotides inhibit apoptosis in WEHI231 B lymphocytes induced by several agents: evidence for blockade of apoptosis at a distal signalling step.”Immunology, vol. 91:586-593.
Medzhitov et al. (1997) “Innate Immunity: The Virtues of a Nonclonal System of Recognition.”Cell, vol. 91:295-298.
Mimori et al. (1986) “Mechanism of Interaction between Ku Protein and DNA.”The Journal of Biological Chemistry, vol. 261 (22):10375-10379.
Mimori et al. (1981) “Characterization fo a High Molecular Weight Acidic Nuclear Protein Recognized by Autoantibodies in Sera from Patients with Polymyositis-Scleroderma Overlap.”J. Clin. Invest., vol. 68:611-620.
Morano et al. (1999) “Heat Shock Factor Function and Regulation in Response to Cellular Stress, Growth, and Differentiation Signals.”Gene Expression, vol. 7:271-282.
Nueda et al. (1999) “DNA-dependent Protein Kinase Protects against Heat-induced Apoptosis.”The Journal of Biological Chemistry, vol. 274 (21):14988-14996.
Reeves (1992) “Antibodies to the p70/p80 (ku) Antigens in systemic Lupus Erythematosus.”Rhem. Dis. Clin. North Am., vol. 18 (2):391-414.
Roman et al. (1997) “Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants.”Nature Medicine, vol. 3 (8):849-854.
Ruiz et al. (1999) “OBA/Ku86: DNA Binding Specificity and Involvement in Mammalian DNA Replication.”Molecular Biology of the Cell, vol. 10:567-580.
Shao et al. (1999) “Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA bny DNA-dependent protein kinase and dissociates RPA: DNA-PK complexes.”The EMBO Journal, vol. 18 (5):1397-1406.
Tsuchiya et al. (1998) “Ku Antigen Binds to Alu Family DNA.”J. Biochem., vol. 123:120-127.
Weaver (1996) “Regulation and Repair of Double-Strand DNA Breaks.”Critical Reviews in Eukaryotic Gene expression, vol. 6 (4):345-375.
Yi et al. (1999) “CpG DNA rescues B cells from apoptosis by activating NFKB and preventing mitochondrial membrane potential disruption via a chloroquine-sensitive pathway.”International Immunology, vol. 11 (12):2015-2024.
Yi et al. (1998) “CpG Oliogodeoxyribonucleotides Rescue Mature Spleen B Cells from Spontaneous Apoptosis and Promote cell Cycle Entry.”The Journal of Immunology, vol. 160: 5898-5906.
Yi et al. (1996) “CpG DNA Rescue of Murine B Lymphoma Cells from Anti-IgM-Induced Growth Arrest and Programmed Cell Death is Associated with Increased Expression of c-myc and bcl-x,”The Journal of Immunology, vol. 157:4918-4925.
Yi et al. (1998) “CpG DNA Rescue from Anti-IgM-Induced WEHI-231 B Lymphoma Apoptosis via Modulation of IκBα and Sustained Activation of Nuclear Factor-κB/c-Rel.”The Journal of Immunology, vol. 160: 1240-1245.
Zou et al. (2000) “Assembly of a Complex Containing Cdc45p, Replication Protein A, and Mcm2p at Replication Origins Controlled by S-Phase Cyclin-Dependent Kinases and Cdc7p-Db4p Kinase.”Molecular and Cellular Biology, vol. 20 (9):3086-3096.
Genbank Acession No. A32626, deposited Nov. 5, 1999.
Genbank Acession No. NP_001460, deposited Oct. 31,2000.
Genbank Acession No. P12956, deposited Oct. 1, 2000.
Genbank Acession No. P13010, deposited Oct. 1, 2000.
Genbank Acession No. S25149, deposited Aug. 26, 1999.

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