Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-01-23
2000-05-09
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
53038826, 5303871, 53038815, 435338, 4352521, G01N 33573, G01N 33577, C07K 1640, C12N 1506
Patent
active
060602538
ABSTRACT:
The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2D6 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 2D6 and lack of specific binding to other human cytochromes P450. The binding agents of the invention are useful in methods for screening drugs for metabolism by cytochrome P450 2D6, and in methods of screening individuals for a poor metabolizing human P450 2D6 phenotype.
REFERENCES:
patent: 5508199 (1996-04-01), Gonzalez et al.
Elaine Buchert et al., "Clinical Implications of Variable Antiarrhythmic Drug Metabolism", (1992) Pharmacogenetics, vol. 2, pp. 2-11.
Cribb et al., "Antipeptide Antibodies Against Overlapping Sequences Differentially Inhibit Human CYP2D6", (1995) Drug Metabolism & Disposition, vol. 23, No. 7, pp. 671-675.
Marja-Liisa Dahl et al., "Genetically Variable Metabolism of Antidepressants and Neuroleptic Drugs in Man", (1993) Pharmacogenetics, vol. 3, pp. 61-70.
S. Wynn Ellis et al., "Catalytic Activities of Human Debrisoquine 4-Hydroxylase Cytochrome P450 (CYP2D6) Expressed in Yeast", (1992) Biochemical Pharmacology, vol. 44, No. 4, pp. 617-620.
Harry V. Gelboin et al., "Inhibitory and Non-Inhibitory Monoclonal Antibodies to Human Cytochrome P450 3A3/4", (1995) Biochemical Pharmacology, vol. 50., No. 11, pp. 1841-1850.
Harry V. Gelboin, "Cytochrome P450 and Monoclonal Antibodies", (1993) Pharmacological Reviews, vol. 45, No. 4, pp. 413-453.
Harry V. Gelboin et al., "Inhibitory and Noninhibitory Monoclonal Antibodies to Human Cytochrome P450 2E1" (1996) Chemical Research in Toxicology, vol. 9. No. 6, pp. 1023-1030.
Elizabeth M.J. Gilliam et al., "Expression of Cytochrome P450 2D6 in Escherichia Coli, Purification, and Spectral and Catalytic Characterization", (Jun. 1, 1995) Archieves of Biochemistry and Biophysics, vol. 319, No. 2, pp. 540-550.
Frank J. Gonzalez et al., "Role of Human Cytochrome P-450s in Risk Assessment and Susceptibility to Environmentally Based Disease", (1993) Journal of Toxicology and Environmental Health, vol. 40, pp. 289-308.
Frank J. Gonzalez et al., "Pharmacogenetic Phenotyping and Genotyping, Present Status and Future Potential" (1994) Clin. Pharmacokinet., vol. 26. No. 1, pp. 59-70.
Frank J. Gonzalez et al., "Human Debrisoquine 4-Hydroxylase (P450LLD1): cDNA and Deduced Amino Acid Sequence and Assignment of the CYP2D Locus to Chromosome 22", (1988) Genomics, vol. 2, pp. 174-179.
Frank J. Gonzalez et al., "Expression of Mammalian Cytochrome P450 Using Baculovirus", (1991) Methods in Enzymology, vol. 206, pp. 93-99.
F.J. Gonzalez et al., "Characterization of the Common Genetic Defect in Humans Deficient in Debrisoquine Metabolism", (Feb. 4, 1988) Nature, vol. 331, No. 6155, pp. 442-446.
Grogan, James et al., "Cytochrome P450 2A1, 2E1, and 2C9 cDNA-Expression By Insect Cells and Partial Purification Using Hydrophobic Chromatography", (1995) Biochemical Pharmacology, vol. 50, No. 9, pp. 1509-1515.
Kristopher W. Krausz et al., "The Production of Inhibitory and Immunoblotting Monoclonal Antibodies to Human Cytochrome P450 2D6", American Society for Pharmacology and Experimental Therapeutics Annual Meeting, San Diego, California, (Mar. 7-11, 1997) 1 page.
T. Kronbach, "Bufuralol, Dextromethorphan, and Debrisoquine As Prototype Substrates for Human P450 2D6", (1991) Methods in Enzymology, vol. 206, pp. 509-517.
Thomayant Prueksaritanont et al., "(+)-Bufuralol 1'-Hydroxylation Activity in Human and Rhesus Monkey Intestine and Liver", (1995) Biochemical Pharmacology, vol. 50, No. 9, pp. 1521-1525.
C. Transon et al., "Interindividual Variability in Catalytic Activity and Immunoreactivity of Three Major Human Liver Cytochrome P450 Isozymes", (1996) Eur. J. Clin. Pharmacol. vol. 51, pp. 79-85.
Hiroshi Yamazaki et al., "Bufuralol Hydroxylation by Cytochrome P450 2D6 and 1A2 Enzymes in Human Liver Microsomes", (1994) Molecular Pharmacology, vol. 46, pp. 568-577.
Ulrich M. Zanger et al., "Antibodies Against Human Cytochrome P-450db1 in Autoimmune Hepatitis Type II", (1988) Proc. Natl. Acad. Sci. USA, vol. 85, pp. 8256-8260.
Gelboin Harry V.
Gonzalez Frank J.
Krausz Kristopher W.
Holleran Anne L.
Hutzell Paula K.
The United States of America as represented by the Department of
LandOfFree
Agents that bind to and inhibit human cytochrome P450 2D6 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Agents that bind to and inhibit human cytochrome P450 2D6, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Agents that bind to and inhibit human cytochrome P450 2D6 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1063739