Agents that bind to and inhibit human cytochrome P450 2C19

Details Agents that bind to and inhibit human cytochrome P450 2C19 Agents that bind to and inhibit human cytochrome P450 2C19

2007-08-28

2007-08-28

Le, Long V. (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007800, C435S069700, C436S015000, C436S548000, C436S547000

Reexamination Certificate

active

10941285

ABSTRACT:
The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 2C19 and lack of specific binding to other human cytochrome P450s. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 2C19, and in methods of measuring P450 2C19 levels in individuals relative to P450 2C19 levels in a control population.

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