Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-06-27
2006-06-27
Weber, Jon (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S012200, C530S300000, C530S324000, C530S350000, C435S006120, C435S007100, C435S366000
Reexamination Certificate
active
07067474
ABSTRACT:
The present invention relates to peptides that affect the interaction of the protein β-catenin with a transcription factor or a tumor suppressor protein. Such peptides are derived either from the amino acids of β-catenin that are known to interact with such proteins, or from the amino acids of the transcription factor or tumor suppressor protein that are known to interact with β-catenin. The effect of the interaction is preferably inhibition of binding of β-catenin and the transcription factor or tumor suppressor protein. Peptide mutants and peptidomimetic compounds are also contemplated in the invention. The peptides, mutands and peptidomimetic compounds of the invention are useful for treating cancer in mammals, and particularly in humans.
REFERENCES:
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Huber et al., Three-Dimensional Structure of the Armadillo Repeat of beta-Catenin, Cell 90, 871-882 (1997).
Hülsken et al. , E-Cadherin and APC Compete for the Interaction with beta-catenin and the Cytoskeleton, The Journal of Cell Biology 127, 2061-2069 (1994)..
Tetsu O and McCormick F, “Beta-Catenin regulates expression of cyclin D1 in colon carcinoma cells”Nature(1999), vol. 398, pp. 422-426.
Birchmeier Walter
Von Kries Jens-Peter
Kam Chih-Min
Max-Delbruck-Centrum fur Molekulare Medizin
Saliwanchik Lloyd & Saliwanchik
Weber Jon
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