Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1990-09-05
1993-07-06
Kepplinger, Esther L.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
435 795, 435975, 436506, 436811, 436827, 436828, G01N 33543
Patent
active
052253520
ABSTRACT:
The invention relates to the use for the diagnosis of demyelinating neuropathies, in particular multiple sclerosis or MS, of endogenous lectins having an affinity for glycans rich in mannose or their protein subunits, these lectins or their subunits being immunologically related to the cerebellar soluble lectins (CSL or their protein subunits, respectively).
REFERENCES:
patent: 4311686 (1982-01-01), Angers et al.
Hukkanen et al., Medline Abs. 83193374.
Smith et al., Ann. Rev. Immunol. 1:175-210, 1983.
Kuchler, et al., Cerebellar Soluble Lectin Is Responsible for Cell Adhesion and Participates in Myelin Compaction in Cultured Rat Oligodendrocytes; Developmental Neuro Science 10: 1988; pp. 199-212.
Zanetta, et al., Isolation and Immunochemical Study of A Soluble Cerebellar Lectin Delineating Its Structure and Function; Journal of Neuro Chemistry 49: 1987; pp. 1250-1257.
Benjamin Gerson et al.; Myelin Basic Protein, Oligoclonal Bands, and IgG in Crebrospinal Fluid as Indicators of Multiple Sclerosis; Clinical Chemistry, vol. 27, No. 12, 1981; pp. 1974-1977.
The Lancet; vol. 335, Jun. 23, 1990 No. 8704; pp. 1482-1484.
Kuchler Sabine
Vincendon Guy
Warter Jean-Marie
Zanetta Jean-Pierre
Centre National de la Recherche Scientifique
Kepplinger Esther L.
Wortman Donna C.
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