Agents for preventing and treating thrombocytopenia

Details Agents for preventing and treating thrombocytopenia Agents for preventing and treating thrombocytopenia

2005-10-18

2005-10-18

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C514S802000, C514S834000, C530S380000, C530S381000, C530S397000, C530S399000

Reexamination Certificate

active

06956022

ABSTRACT:
Method of increasing blood platelet formation by administering a parathyroid hormone (PTH) or at least one PTH derivative as an active ingredient.

REFERENCES:
patent: 3886132 (1975-05-01), Brewer
patent: 4692433 (1987-09-01), Hostetler et al.
patent: 0 748 817 (1996-12-01), None
patent: WO 92 00753 (1992-01-01), None
patent: WO 93 06845 (1993-04-01), None
Benigni, et al; “Inhibition of Human Platelet Aggregation by Parathyroid Hormone”;Am. J. Nephrol, 5:243-247 (1985).
Brickman et al; “Parathyroid Hormone, Platelet Calcium, and Blood Pressure in Normotensive Subjects”;Hypertension, vol. 18, No. 2, pp. 176-182, 1991.
Stedmann's Medical Dictionary, 26thEd.; M. Spraycar, editor, William & Wilkins, Baltimore, 1995.
Meytes,et al; “Effect of Parathyroid Hormone on Erythropoiesis”;J. Clin. Invest. 67:1263-1269; 1981.
Hokom et al; “Pegylated Megakaryocyte Growth and Development Factor Abrogates the Lethal Thrombocytopenia Associated with Carboplatin and Irradiation in Mice”;Blood, 86: No. 12, 4486-4492, 1995.
Herodin et al; “Recombinant Glycosylated Human Interleukin-6 Accelerates Peripheral Blood Platelet Count Recovery in Radiation-Induced Bone Marrow Depression in Baboons”;Blood, vol. 80, No. 3, pp. 688-695; 1992.
Wallace et al; “Thrombocytopoletic Properties of Oncostatin M”;Blood; vol. 86, No. 4, pp. 1310-1315; 1995.
Leonard et al; “Recombinant Human Interleukin-11 Stimulates Multilineage Hematopoietic Recovery in Mice After a Myelosuppressive Regimen of Sublethal Irradiation and Carboplatin”;Blood; vol. 83, No. 6; pp. 1499-1506; 1994.
Shivdasani et al; “Transcription Factor NF-E2 is Required for Platelet Formation Independent of the Actions of Thrombopoietin MGDF in Megakaryocyte Development”;Cell; vol. 81, pp. 695-704, 1995.

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