Agents for potentiating the effects of antitumor agents and comb

Details Agents for potentiating the effects of antitumor agents and comb Agents for potentiating the effects of antitumor agents and comb

1992-06-10

1993-05-04

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 15, 514 33, 514 35, 514 37, 514 43, 514283, 514449, 514656, 514683, A01N 4360, A61K 31495

Patent

active

052082385

ABSTRACT:
Potentiating agents which enhance the efficacy of antineoplastic agents are disclosed. The potentiating agents disclosed are 2-(aminoethylamino) pyridines such as (E)-3-(6-(N-(2-Dimethylaminoethyl)-4-methoxybenzylamino)-2-pyridyl)acrylic acid.

REFERENCES:
patent: 3497596 (1970-02-01), Ursillo
patent: 3993757 (1976-11-01), Freedman
patent: 4590199 (1986-05-01), Coker et al.
patent: 4628047 (1986-12-01), Sakurai et al.
C. Wilson et al., Science 244, "Amplification of a Gene Related to Mammalian mdr Genes in Drug-Resistant Plasmodium Falciparum," 1184-1186 (1989).
"The Merck Index," p. Misc-2 (11th Ed. 1989).

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