Agents containing prostacyclin derivatives for topical applicati

Details Agents containing prostacyclin derivatives for topical applicati Agents containing prostacyclin derivatives for topical applicati

1994-11-30

1997-09-02

Datlow, Philip I.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514573, 514510, 514561, 514469, A61K 31557

Patent

active

056632037

ABSTRACT:
The invention relates to a dermal application form of prostacyclin derivatives of Formula I ##STR1## wherein R.sub.1 means hydrogen or alkyl of 1-10 carbon atoms,
A is a --CH.sub.2 --CH.sub.2 --, trans-CH.dbd.CH-- or --C.ident.C-group,
W represents a hydroxymethyl group which is free or functionally modified at the hydroxy group, the OH-group being in the .alpha.- or .beta.-position,
X is a CH.sub.2 -group or an oxygen atom,
Z is hydrogen or a cyano group,
D means a straight-chain or branched, saturated alkylene group of 1-5 carbon atoms,
E is a --C.ident.C-linkage or a direct bond,
R.sub.2 is a straight- or branched-chain, saturated alkyl group of 1-7 carbon atoms,
R.sub.3 is a free or functionally modified hydroxy group,
and, if R.sub.1 means a hydrogen atom, containing the salts thereof with physiologically compatible bases, for the treatment of ulcerations caused by arterial occlusive diseases, and other skin disorders.

REFERENCES:
patent: 4692464 (1987-09-01), Skuballa et al.
Ekerdt et al, British Journal of Dermatology (1984), III, suppl. 27, pp. 144-146.
Drug Evaluations, 6th Ed. (1986), American Medical Association, pp. 489-490, 1021.

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