Agents containing folic acid, vitamin B6 and vitamin B12,...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S501000, C514S350000, C514S351000, C514S249000, C556S140000, C556S146000, C556S138000, C544S258000, C546S298000, C546S300000

Reexamination Certificate

active

07994142

ABSTRACT:
The invention relates to agents that contain folic acid, vitamin B6 and vitamin B12, and to the use thereof in hyperhomocysteinemia for controlling homocysteine levels. The agents are mainly suitable for the preventive and acute treatment of vascular diseases, of pregnant women and neurodegenerative diseases and are particularly advantageous in cases where the homocysteine levels to be controlled are found in an individual suffering from renal failure or being treated with immune suppressors. The invention particularly relates to pharmaceutical agents and food supplements comprising a corresponding active ingredient combination and to agents in the form of commercial packages containing corresponding combination preparations or monopreparations for the combined use.

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Naurath et al.(I), “Effects of Vitamin B12, Folate, and Vitamin B6 Supple-ments in Elderly People with Normal Serum Vitamin Concentrations,” The Lancet, 346, 85-89 (Jul. 8, 1995).
Naurath et al.(II), “Does a Single Vitamin B-Supplementation Induce Functional Vitamin B-Deficiency?” Clinical Chemistry and Laboratory Medicine, 39(8), 768-771 (2001).
Beers et al. (eds.), Chapter 202 in The Merck Manual of Diagnosis and Therapy, 17th Edition, Merck & Co., Inc., Rahway, NJ, Jan. 1999, only text pp. 1658-1659 have been supplied by applicant.
Bostom et al., “High dose B-vitamin treatment of hyperhomocysteinemia in dialysis patients” Kidney International (1996) vol. 49 pp. 147-152.
Bleie et al., “Changes in basal and postmethionine load concentrations of total homocysteine and cystathionine after B vitamin intervention” American Journal of Clinical Nutrition (2004) vol. 80 pp. 641-648.
Marcucci et al., “Homocysteine-Lowering Therapy and Carotid Intima-Media Thickness in Renal Transplant Recipients” Transplantation Proceedings (2005) vol. 37 pp. 2491-2492.

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