Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-06-05
2007-06-05
Tsang, Cecilia J. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S322000
Reexamination Certificate
active
11190665
ABSTRACT:
Agents for promoting bone deposition and growth in a mammalian subject. The agents are O-glycosylated and non-glycosylated peptides that are derived from vitamin D binding protein, collectively referred to hereinafter as “DBP” peptides. The DBP peptides are from 3 to 18, preferably from 4 to 14 amino acids in length and comprise a sequence which is at least 80% identical, preferably at least 90% identical to the amino acid sequence of a fragment contained within domain III of DBP. Methods for promoting bone deposition in a subject in need of the same are also provided. The methods comprise administering to the subject a therapeutically effective quantity of an agent selected from the group consisting of an activated form of vitamin D binding protein referred to hereinafter as “ADBP”, one or more DBP peptides, and combinations thereof. The agents may be administered locally or systemically.
REFERENCES:
patent: 5641747 (1997-06-01), Popoff et al.
patent: 6103709 (2000-08-01), Norman et al.
patent: 6410269 (2002-06-01), Yamamoto
International Search Report dated Apr. 1, 2003.
“Boning up with Novel Peptides” by Schneider, BioOhio 2000, Nov. 9-10, 2000, Cleveland, Ohio.
“The Anabolic Effect of Vitamin D Binding Protein-Macrophage Activating Factor (DBP-MAF) and a Novel Small Peptide on Bone” by Schneider, et al.,Journal of Bone and Mineral Research, Twenty-Third Annual Meeting of the American Society for Bone and Mineral Research, Phoenix, Arizona, Oct. 12-16, 2001.
Abstract—“The Effects of a Group of Novel Anabolic Peptides on Bone Density and Bone Strength in Adult Rats” by Schneider, et al.,J. Bone&Mineral Research, 2003, Vol. 18 (Suppl. 2) p. S275.
Abstract and Poster Presentation—“The Effects of Novel Anabolic Peptides on Bone Density and Bone Strength in Adult Rats” by Schneider, et al., ASBMR 25th Annual Meeting, Sep. 19-23, 2003, Minneapolis, Minnesota.
Abstract M26—“A Novel Anabolic Peptide Activates Osteogenic Expression in Rat Stromal Cells” by Schneider, et al., The American Society for Bone and Mineral Research (ASBMR) May 24-25, 2004, Hyatt Regency Bethesda, Bethesda, Maryland.
Poster Presentation—“A Novel Anabolic Peptide Activates Osteogenic Expression in Rat Stromal Cells” by Schneider, et al., The American Society for Bone and Mineral Research (ASBMR) May 24-25, 2004, Hyatt Regency Bethesda, Bethesda, Maryland.
Abstract—“pQCT Analysis of the Anabolic Effects of a Group of Novel Small Peptides on Bone in Intact Adult Rats” by Schneider, et al.,J. Bone&Mineral Research, 2002, vol. 17 (Suppl. 1), p. S377.
Poster Presentation—“pQCT Analysis of the Anabolic Effects of a Group of Novel Small Peptides on Bone in Intact Adult Rats” by Schneider, et al.
“Effect of Pharmaceutical Bone Growth Stimulation with Novel Anabolic Peptides: Biomechanical and Bone Density Measurements in a Rat Model” by Askew, et al, Proceedings of IMECE'03, 2003 ASME International Mechanical Engineering Congress & Exposition, Washington, D.C., Nov. 16-21, 2003.
Abstract—“The Anabolic Effect of Vitamin D Biding Protein-Macrophage Activating Factor (DBP-MAF) and a Novel Small Peptide on Bone” by Schneider, et al.,J. Bone&Mineral Research, 2001, vol. 16 (Suppl. 1), p. S231.
Poster Presentation—“The Anabolic Effect of Vitamin D Biding Protein-Macrophage Activating Factor (DBP-MAF) and a Novel Small Peptide on Bone” by Schneider, et al.
“The Anabolic Effects of Vitamin D-Binding Protein-Macrophage Activating Factor (DBP-MAF) and a Novel Small Peptide on Bone” by Schneider, et al.,Critical Reviews in Eukaryotic Gene Expression, 13(2-47):277-284 (2003).
Popoff Steven N.
Safadi Fayez
Schneider Gary B.
Calfee Halter & Griswold LLP
Northeastern Ohio Universities College of Medicine
Teller Roy
Temple University
Tsang Cecilia J.
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