Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides containing saccharide radicals – e.g. – bleomycins – etc.
Reexamination Certificate
2006-05-02
2006-05-02
Campbell, Bruce R. (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Peptides containing saccharide radicals, e.g., bleomycins, etc.
C514S167000, C435S069600, C435S068100, C435S320100
Reexamination Certificate
active
07038010
ABSTRACT:
Agents for promoting bone deposition and growth in a mammalian subject. The agents are O-glycosylated and non-glycosylated peptides that are derived from vitamin D binding protein, collectively referred to hereinafter as “DBP” peptides. The DBP peptides are from 3 to 18, preferably from 4 to 14 amino acids in length and comprise a sequence which is at least 80% identical, preferably at least 90% identical to the amino acid sequence of a fragment contained within domain III of DBP. Methods for promoting bone deposition in a subject in need of the same are also provided. The methods comprise administering to the subject a therapeutically effective quantity of an agent selected from the group consisting of an activated form of vitamin D binding protein referred to hereinafter as “ADBP”, one or more DBP peptides, and combinations thereof. The agents may be administered locally or systemically.
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Abstact—“The Effects of a Group of Novel Anabolic Peptides on Boone Density and Boen Strength in Adult Rats” by Schneider, et al.,J. Bone&Mineral Research, 2003, vol. 18 (Suppl. 2) p. S275.
Abstact and Poster Presentation—“The Effects of Novel Anabolic Peptides on Bone Density and Bone Strength in Adult Rats” by Schneider, et al., ASBMR 25th Annual Meeting, Sep. 19-23, 2003, Minneapolis, Minnesota.
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Abstract—“pQCT Analysis of the Anabolic Effects of a Group of Novel Small Peptides on Bone in Intact Adult Rats” by Schneider, et al.,J. Bone&Mineral Research, 2002, vol. 17 (Supp. 1), p. S377.
Poster Presentation—“pQCT Analysis of the Anabolic Effects of a Group of Novel Small Peptides on Bone in Intact Adult Rats” by Schneider, et al.
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Poster Presentation—“The Anabolic Effect of Vitamin D Binding Protein-Macrophage Activating Factor (DBP-MAF) and a Novel Small Peptide on Bone” by Schneider, et al.
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Popoff Steven N.
Safadi Fayez
Schneider Gary B.
Calfee Halter & Griswold LLP
Campbell Bruce R.
Northeastern Ohio Universities College of Medicine
Teller Roy
Temple University
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