Agents acting at cholecystokinin receptors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514419, 514522, 514539, 514562, 514564, 514586, 514588, 514593, 514595, 514596, 514597, 514598, 548495, 558414, 560 27, 560 29, 562430, 562439, 564 27, 564 39, 564 40, 564 42, 564 48, 564 49, 564 50, 564 51, 564 52, 564 53, 564 54, 564 56, 564 57, C07C27534, C07C27528, A61K 3118, A61K 3117

Patent

active

053896823

ABSTRACT:
The invention concerns a series of novel bis-urea derivatives, nonpeptides, which show good binding affinity for the CCK-B receptor. The compounds, compositions containing them, methods of preparation, and utilities including anxiety, gastric acid secretion inhibition, and psychoses are included.

REFERENCES:
V. Mutt, Gastrointestinal Hormones, G. B. Glass, Ed., Raven Press, New York, 1980, 169-221.
M. Brana, et al., J. of Het. Chem., vol. 24, No. 2, 1987, 369-371.
Y. Dobashi, et al., J. Org. Chem, vol. 52, No. 12, 1987, 2490-2496.
J. Cristol, et al., J. Org. Chem., vol. 42, No. 14, 1977, 2378-2379.
Schick, Yaksh, Go. Regulatory Peptides 1986; 14 : 277-91.
Hill, Hughes, Pittaway. Neuropharmacology 1987; 26: 289-300.
MacVicar, Kerrin, Davison. Brain Research 1987; 406: 130-5.
Roberts, Ferrier, Lee, et.al. Brain Research 1983; 288: 199-211.
Totterdell, Smith. Neuroscience 1986; 19: 181-92.
Weiss, Tanzer, Ettenberg. Pharmacology, Biochemistry, and Behavior 1988; 30: 309-317.
Schneider, Alpert, Iversen. Peptides 1983; 4:749-53.
Konturek. Gastrointestinal Hormones 1980; 23:529-64, ed. G. B. J. Glass, Raven Press, N.Y.
Johnson, ibid. pp. 507-527.
Stadil, ibid. pp. 729-739.
Singh, Walker, Townsend, Thompson. Cancer Research 1986; 46: 1612-16.
Dockray, G J. British Med Bull 1982; 38(3): 253-8.
Morley, J E. Life Sciences 1980; 27: 355-68.
Rehfeld, Gotterman. J. Neurochem 1979; 32: 1339-41.
Della-Fera, Baile. Science 1979; 206: 471-3.
Demeulemeester, H, et.al. J. Neuroscience 1988; 8: 988-1000.
TIPS 1990; 11: 271-273.
Corey, E J. et.al. J Am Chem Soc 1989; 111: 5493-5 and Supplementary Material.
Williams, O F, et.al. J. Am Chem Soc 1959; 81: 4464-9.
Saigo, K. et.al. Bull Chem Soc Japan 1986; 59: 931-2.
Gust, R. et al. J. Med. Chem. 1990; 33: 2535-44.
Smith, J. et al. Gastroenterology 1988; 95: 1541-8.
Mutt. Gastrointestinal Hormones pp. 169-221 (1980).
de Belleroche, J. et al. Ellis Horwood, Chichester, England, 1984; 7:110-27.
Harvey, S. C. The Pharmacological Basis of Therapeutics 7th ed., 1985; 339-71.
Ruschig et al., "New orally effective blood sugar reducing compounds." Arznimittel-Forsch, 8, 448-54 (1958) abst in Cheml Abst. 53(2): 1361g-1317i.
Irakura et al. "Hypoglycemic agents, etc." Yakagaka Zaeshi 84(10) pp. 1017-1026 (1964) abst in Chem Abst 62(3): 3959(e-h).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Agents acting at cholecystokinin receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Agents acting at cholecystokinin receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Agents acting at cholecystokinin receptors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-288642

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.