Agent imparting resistance to external stimuli

Details Agent imparting resistance to external stimuli Agent imparting resistance to external stimuli

2006-01-31

2006-01-31

Weber, Jon (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Glycoprotein, e.g., mucins, proteoglycans, etc.

C514S008100, C435S325000

Reexamination Certificate

active

06992178

ABSTRACT:
The invention provides an agent for conferring resistance comprising a lectin as an effective component, which are able to confer resistance against external stimuli to animal cells, particularly mammalian cells, and to their cultured cells and various tissues in the living bodies. The agent for conferring resistance to external stimulus according to the invention can confer to such animal cells and/or tissues resistance against mechanical stimuli and/or proteolytic reactions, and thereby enhance graft fixation of the cells and/or tissues, as well as transplant tissues obtained by culturing them.

REFERENCES:
Gang, E. et al. Stem Cells 22: 617-624 (2004).
Nishimura et al. Expermental Cell Research 295: 119-127 (2004).
Yan et al. Journal of Biological Chemistry vol. 265, No. 17 10125-10131 (1990).
Cavada et al. Current Protein and Peptide Science vol. 2, No. 2 125-135 (2001).
WO 99/15628.
Kollet, O. et al. Experimental Hematology 28: 726-736 (2000).

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