Agent having a destructive effect on malignant tumors and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S461000

Reexamination Certificate

active

07855191

ABSTRACT:
Disclosed is an agent which has a destructive effect on malignant tumors and contains alpha-ketoglutaric acid, N-acetyl-seleno-L-methionine, N-acetyl-L-methionine, and a compound that is capable of forming azomethine and is selected among the group 5-hydroxymethylfurfural, dehydroascorbic acid, maltol, and vanillin as an active substance, 5-hydroxymethylfurfural being preferred. The inventive agent can be used in the form of an infusion, in an oral or rectal form of administration, or as an irrigation in cancer therapy.

REFERENCES:
patent: 5006551 (1991-04-01), Groke et al.
patent: 0 326 826 (1989-08-01), None
Peckham et al ‘Oxford Texbook of Oncology’ Oxford University Press, vol. 1, p. 451, 1995.
Menter et al ‘Selenium Effects on Prostate cell growth’ Cancer Epidemiology, Biomarkers and Prevention, vol. 9, p. 1171-1182, 2000.
Bommarius ‘L-methionine and related L-amino acids by acylase cleavage of their corresponding N-acetyl-DL-derivatives’ Tetrahedron, vol. 8 (19), p. 3197-3200, 1997.
Millis et al ‘Growth inhibition of subcutaneously transplanted hepatomas without cachexia by alteration of the dietary arginine-methionine balance’ Nutrition and Cancer, 31(1), p. 41-55, 1998.

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