Agent for treatment of inflammatory bowel disease

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S885000

Reexamination Certificate

active

10748490

ABSTRACT:
The present invention provides a therapeutic agent for treating inflammatory bowel diseases comprising as an active ingredient at least one member selected from polypeptides belonging a family exhibiting thioredoxin activity.

REFERENCES:
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Tagaya, et al., “ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction,” The EMBO Journal vol. 8, No. 3, pp. 757-764 published in 1989.
Powis, et al., “Properties and Biological Activities of Thioredoxins,” Annual Reviews in Biphysics and Biomolecular Structure: 30 pp. 421-455 published in 2001.
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Williams, et al., “Enhanced Survival and Mucosal Repair After Dextran Sodium Sulfate-Induced Colitis in Transgenic Mice That Overexpress Growth Hormone,” Gastroenterology; 120 pp. 925-937 published in 2001.
Kruidenier, et al., “Review article: oxidative stress as a pathogenic factor in inflammatory bowel disease—radicals or riduculous?” Alimentart Pharmacology & Therpeutics; 16 pp. 1997-2015 published in 2002.
Nakamura, et al., “Circulating thioredoxin suppresses lipopolysaccharide-induced neutrophil chemotaxis,” Proceedings of the National Academy of Science of the United States of America vol. 98, No. 26 pp. 15143-15148 published in Dec. 18, 2001.
Nakamura, et al., “Chronic elevation of plasma thioredoxin: Inhibition of chemotaxis and curtailment of life expectancy in AIDS,” Proceedings of the National Academy of Science of the United States of America vol. 98, No. 5 pp. 2688-2693 published in Feb. 27, 2001.
Powis, et al., “Properties and Biological Activities of Thioredoxins,” Annual Reviews of Pharmacology and Toxicology 41 pp. 216-295 published in 2001.

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