Agent for treatment of disorders of the cerebro-neural transmiss

Details Agent for treatment of disorders of the cerebro-neural transmiss Agent for treatment of disorders of the cerebro-neural transmiss

1990-02-28

1992-02-11

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 514253, 544360, 544364, 544396, 544398, 544403, A61K 31495, C07D29508

Patent

active

050876279

ABSTRACT:
A method for treatment of disorders of the cerebro-neural transmission system which comprises administering a compound of the formula (I) or a pharmaceutically acceptable salt thereof in a therapeutically effective amount, either alone or in admixture with one or more pharmaceutically acceptable excipients, ##STR1## wherein Ar or Ar' is unsubstituted or substituted phenyl or pyridyl; R is hydrogen, lower alkyl, lower alkoxy, halogen or lower alkylenedioxy; A is C.sub.1 -C.sub.6 alkylene; and n is 0 or 1. A compound of the formula (II) or a pharmaceutically acceptable salt thereof, ##STR2## wherein R.sup.1 is hydrogen or fluorine; R.sup.2 is hydrogen or fluorine; R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halogen or lower alkylenedioxy; A is lower C.sub.1 -C.sub.6 alkylene, and n is 0 or 1, provided that at least one of R.sup.1 or R.sup.2 is fluorine.

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patent: 4656175 (1987-04-01), Bjork et al.
patent: 4757074 (1988-07-01), Coker et al.
R. P. Shank et al., "Preclinical Evaluation of McN-5707 as a Potential Antidepressant", J. Pharm. Exp. Ther., vol. 242, No. 1, pp. 74-84.
C. Idzikowski et al., "5-Hydroxytryptamine-2 antagonist increases human slow wave sleep", Brain Research, 378 (1986), pp. 164-168.
Irwin Lucki et al., "Differential Actions of Serotonin Antagonists on Two Behavioral Models of Serotonin Receptor Activation in the Rat", J. Pharm. Exp. Ther., vol. 228, (1984) pp. 133-139.
Nishimura et al., Chemical Abstract, 109579j, vol. 89 (1978) p. 932.
Iwao et al., Chemical Abstract, 149568t, vol. 109 (1988), p. 742.

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