Agent for treatment of cerebrovascular contraction

Details Agent for treatment of cerebrovascular contraction Agent for treatment of cerebrovascular contraction

1992-02-13

1993-08-24

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514466, A61K 31155, A61K 3136

Patent

active

052389642

ABSTRACT:
A method for the treatment of cerebrovascular contraction in mammals involving administration of a pharmaceutical composition containing as an effective ingredient a p-guanidinobenzoic acid derivative represented by the formula ##STR1## wherein R denotes a group represented by the formula ##STR2## or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

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Kreil, E., et al., "Nafamstat mesilate attenuates pulmonary hypertension in heparin-protamine reactions", J. Appl. Physiol. (1989), vol. 67, pp. 1463-1471.
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