Drug – bio-affecting and body treating compositions – Lymphokine
Reexamination Certificate
1997-09-04
2001-05-29
Kemmerer, Elizabeth (Department: 1646)
Drug, bio-affecting and body treating compositions
Lymphokine
C514S002600, C514S012200, C514S071000, C514S198000
Reexamination Certificate
active
06238659
ABSTRACT:
This is a national phase filing of the Application No. PCT/DE95/01395, which was filed with the Patent Corporation Treaty on Oct. 5, 1995, and is entitled to priority of the German Patent Application P 44 35 661.7 filed Oct. 5, 1994.
I. FIELD OF THE INVENTION
The present invention relates to the use of a preparation comprising a substance influencing the cellular redox state for treating papilloma virus-positive malignant and premalignant lesions.
II. BACKGROUND OF THE INVENTION
It is well known to treat lesions which are caused by human-pathogenic papilloma viruses (HPV) by the application of cytokines, such as &agr;-tumor necrosis factor and interferons. For this purpose, cytokines are administered in high doses. The treatment of patients exposed to high cytokine doses is accompanied by considerable side-effects such as cachexia, queasiness, vomiting and headache.
Therefore, it is the object of the present invention to provide a preparation for treating papilloma virus-positive malignant and premalignant lesions, by which the above side-effects are reduced.
According to the invention this is achieved by using a preparation comprising a substance influencing the cellular redox state.
III. SUMMARY OF THE INVENTION
The present invention relates to a preparation comprising a substance influencing the cellular redox state for treating papilloma virus-positive malignant lesions.
IV. DETAILED DESCRIPTION OF THE INVENTION
The expression “a substance influencing the cellular redox state” comprises compounds of any kind which can reduce the redox state of cells, particularly of host cells of papilloma viruses. They may be, e.g., exogenous compounds. Examples of the above compounds are antioxidants such as pyrrolidine-dithiocarbamate (PDTC) and derivatives thereof. The compounds included in the preparation used according to the invention may also be metabolized into the actual substance influencing the cellular redox state as late as in the cell to be treated.
The preparations used according to the invention may also contain several of the substances.
In order for the modulator substance to display its effect, it has to be both intracellularly and extracellularly sufficiently stable within the body, i.e., it may not be metabolized to give an ineffective compound before it has displayed its effect. A person skilled in the art knows which factors influence the stability. Moreover, he knows for how long a compound has to be stable to display its effect. In addition, he is familiar with tests of how to determine the stability of the compounds.
In a preferred embodiment, the preparation also includes a cytokine. Examples thereof are interferons and &agr;-tumor necrosis factor (TNF-&agr;). Recombinant interferon and recombinant &agr;-TNF are used preferably. The cytokine dose administered with the preparations used according to the invention is lower than the cytokine dose administered so far. Thus, the positive effect of cytokines can be achieved by the preparation used according to the invention without resulting in the above drawbacks thereof. The effect of the substance influencing the cellular redox state is also increased when a cytokine is present.
Conjugates according to the invention distinguish themselves in that they have little side-effects. Thus, they are suited in the best possible way for the treatment of papilloma virus-positive, particularly HPV-positive, malignant and premalignant lesions such as carcinomas of the genital zone. This also includes warts.
The below examples explain the invention in more detail. The following preparations and examples are given to enable those skilled in the art to more clearly understand and to practice the present invention. The present invention, however, is not limited in scope by the exemplified embodiments, which are intended as illustrations of single aspects of the invention only, and methods which are functionally equivalent are within the scope of the invention. Indeed, various modifications of the invention in addition to those described herein will become apparent to those skilled in the art from the foregoing description. Such modifications are intended to fall within the scope of the appended claims.
REFERENCES:
patent: 5686436 (1997-11-01), Van Dyke
patent: 2113683 (1995-07-01), None
patent: 0 527 241 A1 (1993-02-01), None
Rösl et al., 1994, “Differential Regulation of the JE Gene Encoding the Monocyte Chemoattractant Protein (MCP-1) in Cervical Carcinoma Cells and Derived Hybrids,”J. Virol.68(4):2142-2150.
Rösl Frank
zur Hausen Harald
Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Recht
Kemmerer Elizabeth
Pennie & Edmonds LLP
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