Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-08-07
1998-11-03
Elliott, George C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 9131, C07H 2100, C12P 1934
Patent
active
058310673
ABSTRACT:
Agents for stimulating the dividing activity of mammalian cells are presented, which have as an active substance a nucleotide sequence with a complimentary sequence (anti-sense) to a domain of the mRNA of tumor suppressor retinoblastoma or p16 genes acting on cell dividing activity. For Rb, the agents are nucleotide sequences
5'-GGTTTTGGGCGGCATGAC-3' (SEQ ID NO: 1) and
5'-CTCAGTAAAAGTGAACGA-3' (SEQ ID NO: 2); a nucleotide sequence comprising 49 base pairs, wherein the domain of the mRNA comprises nucleotides 124 to 152; and a 360 base pair nucleotide wherein the domain of the mRNA comprises an Hpa I restriction endonuclease site, an ASP718 endonuclease site, a portion of the 5' untranslated domain of the Rb gene, and a first exon of the Rb gene. For p16, the agent comprises GATCCATGCT GCTCC (SEQ ID NO: 3).
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Lieber Andre
Strauss Michael
Brusca John S.
Elliott George C.
Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.v.
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